ReviewJournal of applied genetics2016
Molecular basis of hypohidrotic ectodermal dysplasia: an update.
Review in Journal of applied genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Research progress on the diagnosis of ectodermal dysplasia and early oral prosthodontic treatment].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Pooled it
- Article
- A case study of a novel homozygous EDAR splice site variant in hypohidrotic ectodermal dysplasia with tooth agenesis: molecular dynamics insights.BMC medical genomics · 2025Article
- X-linked hypohidrotic ectodermal dysplasia associated with gastroesophageal reflux disease.Molecular genetics and metabolism reports · 2025Article
- Article
- Skin Development and Disease: A Molecular Perspective.Current issues in molecular biology · 2024Review
- A Novel Ectodysplasin a Gene mutation of X-Linked Hypohidrotic Ectodermal Dysplasia.Clinical, cosmetic and investigational dermatology · 2024Article
- Article
- The Ectodermal Dysplasias-Burden of Disease Score: Development and Validation of an Ectodermal Dysplasia Family/Parental Burden Score.Acta dermato-venereologica · 2023Article
- Unexplained Fever in Infancy: Report of a Rare Case of Hypohidrotic Ectodermal Dysplasia in an Infant.Cureus · 2023Article
- Co-Occurrence of Hypohidrotic Ectodermal Dysplasia and Food Protein-Induced Enterocolitis Syndrome: A Report of a New Ectodysplasin A Variant.Skin appendage disorders · 2023Article
- Potential Risks of Corneal Refractive Surgery in Patients with Ectodermal Dysplasia.Ophthalmology and therapy · 2022Article
- Article
- Hypohidrotic ectodermal dysplasia: A case report with review and latest updates.Journal of oral and maxillofacial pathology : JOMFP · 2022Article
- Compendium of causative genes and their encoded proteins for common monogenic disorders.Protein science : a publication of the Protein Society · 2022Article
- Three Variants Affecting Exon 1 ofFrontiers in genetics · 2022Article
- Two novel ectodysplasin A gene mutations and prenatal diagnosis of X-linked hypohidrotic ectodermal dysplasia.Molecular genetics & genomic medicine · 2021Article
- Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia.Orphanet journal of rare diseases · 2021Article
- The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets.Life science alliance · 2021Article
- A novel EDAR missense mutation identified by whole-exome sequencing with non-syndromic tooth agenesis in a Chinese family.Molecular genetics & genomic medicine · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.