Trial reportEuropean journal of nuclear medicine and molecular imaging2016
Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects.
Trial report in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.Biological psychiatry · 2018Pooled it
- Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [Molecular imaging and biology · 2019Trial
- Kinetic modelling of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Trial
- Imaging Microtubule Dynamics In Vivo in Human Brain: Optimal Quantification Based on a Test-Retest Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- TSPO circadian pattern: a test-retest study of [European journal of nuclear medicine and molecular imaging · 2025Article
- A [Journal of neuroinflammation · 2025Article
- Test-retest properties of [EJNMMI research · 2025Article
- Does seasonal variation affect the neuroimmune system? A retrospective [Neuroscience letters · 2024Article
- Evaluation of microglia activation related markers following a clinical course of TBS: A non-human primate study.PloS one · 2024Article
- Microglial Positron Emission Tomography Imaging In Vivo : Positron Emission Tomography Radioligands: Utility in Research and Clinical Practice.Advances in neurobiology · 2024Review
- Parametric and non-parametric Poisson regression for modelling of the arterial input function in positron emission tomography.EJNMMI physics · 2023Article
- From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research.International journal of molecular sciences · 2023Review
- A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod.Brain communications · 2023Article
- Translocator protein PET imaging in temporal lobe epilepsy: A reliable test-retest study using asymmetry index.Frontiers in neuroimaging · 2023Article
- Comparison of Invasive and Non-invasive Estimation of [Molecular imaging and biology · 2022Article
- Imaging Histamine H3 Receptors with Positron Emission Tomography.Current topics in behavioral neurosciences · 2022Review
- Applicability, potential and limitations of TSPO PET imaging as a clinical immunopsychiatry biomarker.European journal of nuclear medicine and molecular imaging · 2021Review
- Early stopping in clinical PET studies: How to reduce expense and exposure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Review
- Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study.European journal of nuclear medicine and molecular imaging · 2021Article
- Neuroinflammation is highest in areas of disease progression in semantic dementia.Brain : a journal of neurology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe PET radioligand [(11)C]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation. We examined the reproducibility of [(11)C]PBR28 binding in healthy subjects with quantification on a regional and voxel-by-voxel basis. In addition, we performed a preliminary analysis of diurnal changes in TSPO availability.
methodsTwelve subjects were examined using a high-resolution research tomograph and [(11)C]PBR28, six in the morning and afternoon of the same day, and six in the morning on two separate days. Regional volumes of distribution (V T) were derived using a region-of-interest based two-tissue compartmental analysis (2TCM), as well as a parametric approach. Metabolite-corrected arterial plasma was used as input function.
resultsFor the whole sample, the mean absolute variability in V T in the grey matter (GM) was 18.3 ± 12.7 %. Intraclass correlation coefficients in GM regions ranged from 0.90 to 0.94. Reducing the time of analysis from 91 to 63 min yielded a variability of 16.9 ± 14.9 %. There was a strong correlation between the parametric and 2TCM-derived GM values (r = 0.99). A significant increase in GM V T was observed between the morning and afternoon examinations when using secondary methods of quantification (p = 0.028). In the subjects examined at the same time of the day, the absolute variability was 15.9 ± 12.2 % for the 91-min 2TCM data.
conclusionV T of [(11)C]PBR28 binding showed medium reproducibility and high reliability in GM regions. Our findings support the use of parametric approaches for determining [(11)C]PBR28 V T values, and indicate that the acquisition time could be shortened. Diurnal changes in TSPO binding in the brain may be a potential confounder in clinical studies and should be investigated further.
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