ArticleScientific reports2015
Chimeric peptide constructs comprising linear B-cell epitopes: application to the serodiagnosis of infectious diseases.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Designing of a Multi-Epitope Antigen for Toxocariasis Diagnosis: An in Silico Approach.Acta parasitologica · 2025Article
- Tick exposure biomarkers: A One Health approach to new tick surveillance tools.Current research in parasitology & vector-borne diseases · 2024Article
- Utilizing Protein-Peptide Hybrid Microarray for Time-Resolved Diagnosis and Prognosis of COVID-19.Microorganisms · 2023Article
- Stability Assessment of Four Chimeric Proteins for Human Chagas Disease Immunodiagnosis.Biosensors · 2021Article
- Identification of a universal antigen epitope of influenza A virus using peptide microarray.BMC veterinary research · 2021Article
- Identification and Mapping of HBsAg Loss-Related B-Cell Linear Epitopes in Chronic HBV Patients by Peptide Array.Frontiers in immunology · 2021Article
- In Silico Design and Validation of OvMANE1, a Chimeric Antigen for Human Onchocerciasis Diagnosis.Pathogens (Basel, Switzerland) · 2020Article
- Epitope-Containing Short Peptides Capture Distinct IgG Serodynamics That Enable Differentiating Infected from Vaccinated Animals for Live-Attenuated Vaccines.Journal of virology · 2020Article
- Identification of a Novel Linear B Cell Epitope on the Sao Protein ofFrontiers in immunology · 2020Article
- Multi-peptide ELISAs overcome cross-reactivity and inadequate sensitivity of conventional Chlamydia pneumoniae serology.Scientific reports · 2019Article
- MGMT autoantibodies as a potential prediction of recurrence and treatment response biomarker for glioma patients.Cancer medicine · 2019Article
- A novel synthetic peptide microarray assay detects Chlamydia species-specific antibodies in animal and human sera.Scientific reports · 2018Article
- An evaluation of a recombinant multiepitope based antigen for detection of Toxoplasma gondii specific antibodies.BMC infectious diseases · 2017Article
- Evolving serodiagnostics by rationally designed peptide arrays: the Burkholderia paradigm in Cystic Fibrosis.Scientific reports · 2016Article
- Designing a Multi-Epitope Antigen for Serodiagnosis ofAvicenna journal of medical biotechnologyArticle
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linear B-cell epitopes are ideal biomarkers for the serodiagnosis of infectious diseases. However, the long-predicted diagnostic value of epitopes has not been realized. Here, we demonstrated a method, diagnostic epitopes in four steps (DEIFS), that delivers a combination of epitopes for the serodiagnosis of infectious diseases with a high success rate. Using DEIFS for malaria, we identified 6 epitopes from 8 peptides and combined them into 3 chimeric peptide constructs. Along with 4 other peptides, we developed a rapid diagnostic test (RDT), which is able to differentiate Plasmodium falciparum (P. falciparum) from Plasmodium vivax (P. vivax) infections with 95.6% overall sensitivity and 99.1% overall specificity. In addition to applications in diagnosis, DEIFS could also be used in the diagnosis of virus and bacterium infections, discovery of vaccine candidates, evaluation of vaccine potency, and study of disease progression.
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