Evidence map›Paper›PMID 26293554›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2015

Chronic Exposure to Particulate Chromate Induces Premature Centrosome Separation and Centriole Disengagement in Human Lung Cells.

Julieta Martino, Amie L Holmes, Hong Xie, Sandra S Wise, John Pierce Wise

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. A whale of a tale: whale cells evade the driving mechanism for hexavalent chromium-induced chromosome instability.Toxicological sciences : an official journal of the Society of Toxicology · 2024
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  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Julieta Martino*Wise Laboratory of Environmental and Genetic Toxicology and Department of Applied Medical Sciences, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104; and.
Amie L Holmes*Wise Laboratory of Environmental and Genetic Toxicology and Department of Applied Medical Sciences, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104; and.
Hong Xie*Wise Laboratory of Environmental and Genetic Toxicology and Department of Applied Medical Sciences, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104; and.
Sandra S Wise*Wise Laboratory of Environmental and Genetic Toxicology and Department of Applied Medical Sciences, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104; and Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40068.
John Pierce Wise*Wise Laboratory of Environmental and Genetic Toxicology and Department of Applied Medical Sciences, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104; and Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40068 john.wise@louisville.edu.
Society of Environmental Toxicology and Chemistry · USUniversity of Louisville · US

Funding

PARTICULATE CR(VI) TOXICOLOGY IN HUMAN LUNG EPITHELIAL CELLS AND FIBROBLASTS (Admin Supplement/PA-17-055)R01ES016893 · NIEHS · UNIVERSITY OF SOUTHERN MAINE · PI WISE, JOHN PIERCE · 2009 to 2021
$5.1M
NIEHS NIH HHS ES016893NIEHS NIH HHS R01 ES016893
6 · The paper itself

Abstract

Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. Lung tumors are characterized by structural and numerical chromosome instability. Centrosome amplification is a phenotype commonly found in solid tumors, including lung tumors, which strongly correlates with chromosome instability. Human lung cells exposed to Cr(VI) exhibit centrosome amplification but the underlying phenotypes and mechanisms remain unknown. In this study, we further characterize the phenotypes of Cr(VI)-induced centrosome abnormalities. We show that Cr(VI)-induced centrosome amplification correlates with numerical chromosome instability. We also show chronic exposure to particulate Cr(VI) induces centrosomes with supernumerary centrioles and acentriolar centrosomes in human lung cells. Moreover, chronic exposure to particulate Cr(VI) affects the timing of important centriolar events. Specifically, chronic exposure to particulate Cr(VI) causes premature centriole disengagement in S and G2 phase cells. It also induces premature centrosome separation in interphase. Altogether, our data suggest that chronic exposure to particulate Cr(VI) targets the protein linkers that hold centrioles together. These centriolar linkers are important for key events of the centrosome cycle and their premature disruption might underlie Cr(VI)-induced centrosome amplification.

Indexed as

Cell LineCentriolesCentrosomeChromatesChromiumChromosomal InstabilityHumansLungParticulate MatterZinc CompoundsChromatesChromiumchromium hexavalent ionParticulate Matterzinc chromateZinc Compoundscentriole disengagementcentrosome amplificationcentrosome separationchromiumCIN

Identifiers

PMID26293554
PMCPMC4635651
OpenAlexW2185312002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.