Evidence map›Paper›PMID 26293462›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133+ Circulating Angiogenic Cells.

Natasha DeJarnett, Ray Yeager, Daniel J Conklin, Jongmin Lee, Timothy E O'Toole, James McCracken, Wes Abplanalp, Sanjay Srivastava, Daniel W Riggs, Ihab Hamzeh and 16 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. The Green Heart Project: objectives, design, and methods.American journal of epidemiology · 2026
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  2. Exposure to Toxic Compounds Using Alternative Smoking Products: Analysis of Empirical Data.International journal of environmental research and public health · 2025
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  3. Article
  4. The Green Heart Project: Objectives, Design, and Methods.medRxiv : the preprint server for health sciences · 2023
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Green environments and cardiovascular health.Trends in cardiovascular medicine · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Characteristics of air quality and sources affecting high levels of PMEnvironmental monitoring and assessment · 2018
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Natasha DeJarnettFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Ray YeagerFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Daniel J ConklinFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Jongmin LeeFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Timothy E O'TooleFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
James McCrackenFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Wes AbplanalpFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Sanjay SrivastavaFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Daniel W RiggsFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Ihab HamzehFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Stephen WagnerFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Atul ChughFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Andrew DeFilippisFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Tiffany CiszewskiFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Brad WyattFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Carrie BecherFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Deirdre HigdonFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Kenneth S RamosFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
David J TollerudFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
John A MyersFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Shesh N RaiFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Jasmit ShahFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Nagma ZafarFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Sathya S KrishnasamyFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Sumanth D PrabhuFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.).
Aruni BhatnagarFrom the Diabetes and Obesity Center (N.D., R.Y., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., A.C., A.D., T.C., B.W., S.N.R., J.S., N.Z., S.S.K., A.B.), Department of Environmental and Occupational Health Sciences (N.D., R.Y., D.J.T.), Institute of Molecular Cardiology (N.D., D.J.C., J.L., T.E.O., J.M., W.A., S.S., D.W.R., S.W., A.C., A.D., T.C., B.W., C.B., D.H., J.S., S.D.P., A.B.), Department of Pediatrics (J.A.M.), Department of Bioinformatics and Biostatics (S.N.R.), Biostatistics Shared Facility, JG Brown Cancer Center (S.N.R.), Division of Endocrinology, Metabolism and Diabetes, Department of Medicine (S.S.K.), and Department of Biochemistry and Molecular Biology (K.S.R., A.B.), University of Louisville, KY; Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (I.H.); Department of Medicine, Johns Hopkins University, Baltimore, MD (A.D.); and Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham (S.D.P.) aruni@louisville.edu.

Funding

Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1M
Role of Platelet Activation and Vascular Pathology in Aldehyde ToxicityP01ES011860 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI BHATNAGAR · 2003 to 2007
$7.0M
Endothelial Progenitor Cells and Particulate Air PollutionR01ES019217 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI, O'TOOLE, TIMOTHY E · 2011 to 2022
$6.0M
NHLBI NIH HHS P50 HL120163NIEHS NIH HHS ES019217NIEHS NIH HHS ES11860NIEHS NIH HHS P01 ES011860NIEHS NIH HHS R01 ES019217
6 · The paper itself

Abstract

objectivesPrevious studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells. APPROACH AND

resultsIn a cross-sectional study, cardiovascular disease risk factors, blood levels of C-reactive protein, and 15 antigenically defined circulating angiogenic cell populations were measured in participants (n=316) with moderate-to-high cardiovascular disease risk. Attributes of roadways surrounding residential locations were assessed using geographic information systems. Associations between road proximity and cardiovascular indices were analyzed using generalized linear models. Close proximity (<50 m) to a major roadway was associated with lower income and higher rates of smoking but not C-reactive protein levels. After adjustment for potential confounders, the levels of circulating angiogenic cells in peripheral blood were significantly elevated in people living in close proximity to a major roadway (CD31(+)/AC133(+), AC133(+), CD34(+)/AC133(+), and CD34(+)/45(dim)/AC133(+) cells) and positively associated with road segment distance (CD31(+)/AC133(+), AC133(+), and CD34(+)/AC133(+) cells), traffic intensity (CD31(+)/AC133(+) and AC133(+) cells), and distance-weighted traffic intensity (CD31(+)/34(+)/45(+)/AC133(+) cells).

conclusionsLiving close to a major roadway is associated with elevated levels of circulating cells positive for the early stem marker AC133(+). This may reflect an increased need for vascular repair. Levels of these cells in peripheral blood may be a sensitive index of cardiovascular injury because of residential proximity to roadways.

Indexed as

AutomobilesResidence CharacteristicsVehicle EmissionsAC133 AntigenAdultAntigens, CDBiomarkersCell CountCross-Sectional StudiesEndothelial Progenitor CellsEnvironmental ExposureEnvironmental PollutantsFemaleGlycoproteinsHumansInflammation MediatorsAC133 AntigenAntigens, CDBiomarkersEnvironmental PollutantsGlycoproteinsInflammation MediatorsPeptidesPROM1 protein, humanVehicle Emissionsair pollutioncardiovascular diseasesendothelial progenitor cellsepidemiologyrisk factors

Identifiers

PMID26293462
PMCPMC4862408

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