ArticleNeuroradiology2015
Supratentorial white matter blurring associated with voltage-gated potassium channel-complex limbic encephalitis.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- An Anti-NHInternal medicine (Tokyo, Japan) · 2026Review
- Autoimmune encephalitis: Early and late findings on serial MR imaging and correlation to treatment timepoints.European journal of radiology open · 2024Article
- Specific B- and T-cell populations are associated with cognition in patients with epilepsy and antibody positive and negative suspected limbic encephalitis.Journal of neurology · 2021Observational
- Psychiatric Manifestation of Anti-LGI1 Encephalitis.Brain sciences · 2020Article
- Article
- Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.AJNR. American journal of neuroradiology · 2019Article
- Conventional brain MRI features distinguishing limbic encephalitis from mesial temporal glioma.Neuroradiology · 2019Article
- A Patient with Limbic Encephalitis Associated with Anti-leucine-rich Glioma-inactivated 1 (LGI1) Antibody Presenting with Slowly Progressive Cognitive Impairment and Fluctuating Striatal Lesions.Internal medicine (Tokyo, Japan) · 2019Article
- Selective Limbic Blood-Brain Barrier Breakdown in a Feline Model of Limbic Encephalitis with LGI1 Antibodies.Frontiers in immunology · 2017Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLimbic encephalitis (LE) associated with voltage-gated potassium channel-complex antibodies (VGKC-LE) is frequently non-paraneoplastic and associated with marked improvement following corticosteroid therapy. Mesial temporal lobe abnormalities are present in around 80 % of patients. If associated or preceded by faciobrachial dystonic seizures, basal ganglia signal changes may occur. In some patients, blurring of the supratentorial white matter on T2-weighted images (SWMB) may be seen. The purpose of this study was to evaluate the incidence of SWMB and whether it is specific for VGKC-LE.
methodsTwo experienced neuroradiologists independently evaluated signal abnormalities on FLAIR MRI in 79 patients with LE while unaware on the antibody type.
resultsSWMB was independently assessed as present in 10 of 36 (28 %) compared to 2 (5 %) of 43 non-VGKC patients (p = 0.009). It was not related to the presence of LGI1 or CASPR2 proteins of VGKC antibodies. MRI showed increased temporomesial FLAIR signal in 22 (61 %) VGKC compared to 14 (33 %) non-VGKC patients (p = 0.013), and extratemporomesial structures were affected in one VGKC (3 %) compared to 11 (26 %) non-VGKC patients (p = 0.005).
conclusionSWMB is a newly described MRI sign rather specific for VGKC-LE.
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