ArticleNeuroradiology2015
Alterations in white matter volume and its correlation with clinical characteristics in patients with generalized anxiety disorder.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging.NeuroImage. Clinical · 2019Pooled it
- Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Association of white matter volume with sleep quality: a voxel-based morphometry study.Brain imaging and behavior · 2022Article
- Examining Brain Structures Associated With Emotional Intelligence and the Mediated Effect on Trait Creativity in Young Adults.Frontiers in psychology · 2018Article
- Biological markers of generalized anxiety disorder.Dialogues in clinical neuroscience · 2017Review
- Cortical functional activity in patients with generalized anxiety disorder.BMC psychiatry · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOnly a few morphological studies have focused on changes in white matter (WM) volume in patients with generalized anxiety disorder (GAD). We evaluated alterations in WM volume and its correlation with symptom severity and duration of illness in adults with GAD.
methodsThe 44 subjects were comprised of 22 patients with GAD (13 males and nine females) diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) and 22 age-matched healthy controls (13 males and nine females). High-resolution magnetic resonance imaging (MRI) data were processed by voxel-based morphometry (VBM) analysis based on diffeomorphic anatomical registration using the exponentiated Lie algebra (DARTEL) algorithm in SPM8.
resultsPatients with GAD showed significantly reduced WM volume, particularly in the dorsolateral prefrontal cortex (DLPFC), anterior limb of the internal capsule (ALIC), and midbrain. In addition, DLPFC volume was negatively correlated with GAD-7 score and illness duration. ALIC volume was negatively correlated with GAD-7 score. Female patients had significantly less orbitofrontal cortex volume compared to that in male patients.
conclusionThe findings demonstrate localized changes in WM volume associated with cognitive and emotional dysfunction in patients with GAD. The finding will be helpful for understanding the neuropathology in patients with GAD.
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