Evidence map›Paper›PMID 26292957›Full record

ArticleWorld journal of surgical oncology2015

Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma.

Yin-Ping Hsu, Chia-Hsun Hsieh, Hui-Tzu Chien, Chi-Hsiung Lai, Chung-Kan Tsao, Chun-Ta Liao, Chung-Jan Kang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Shiang-Fu Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  12. Clinical relevance of CYFRA 21-1 as a tumour marker in patients with oropharyngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
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  14. CYFRA 21-1: a suitable tumor marker in patients with head and neck cutaneous squamous cell carcinoma?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yin-Ping HsuDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. d8324@cgmh.org.tw.
Chia-Hsun HsiehDepartment of Medical Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. wisdom5000@gmail.com.
Hui-Tzu ChienDepartment of Public Health, Chang Gung University, Taoyuan, Taiwan, Republic of China. kathy.htchien@gmail.com.
Chi-Hsiung LaiDepartment of Public Health, Chang Gung University, Taoyuan, Taiwan, Republic of China. urinebeario@hotmail.com.
Chung-Kan TsaoDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University, Taoyuan, Taiwan, Republic of China. nightman@ms8.hinet.net.
Chun-Ta LiaoDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. liaoct@adm.cgmh.org.tw.
Chung-Jan KangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. handneck@gmail.com.
Hung-Ming WangDepartment of Medical Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. whm526@adm.cgmh.org.tw.
Joseph Tung-Chieh ChangDepartment of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, Republic of China. cgmhnog@gmail.com.
Shiang-Fu HuangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Shin Street, Kwei-Shan, Linkou, Taoyuan, 333, Taiwan, Republic of China. bigmac@adm.cgmh.org.tw.
Chang Gung Memorial Hospital · TWChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCYFRA 21-1 (cytokeratin 19 fragment) and C-reactive proteins (CRP) were separately reported to be associated with prognosis of head and neck squamous cell carcinoma. The combined roles of CYFRA 21-1 and CRP levels were rarely investigated in oral squamous cell carcinoma (OSCC). The purpose of the present study was to analyze the relationship between preoperative levels of both CYFRA 21-1 and CRP, with clinicopathological factors and prognosis in OSCC patients.

methodsA retrospective study was performed on 130 OSCC patients between December 2010 and June 2013. Their serum CYFRA 21-1 and CRP levels were measured preoperatively.

resultsCYFRA 21-1 level of ≥3.3 ng/mL and CRP level of ≥5.0 mg/L were significantly associated with pathological tumor status (P<0.001), tumor depth (>10 vs. ≤10 mm, P=0.001), bone invasion (P=0.001), skin invasion (P=0.006), pathologic nodal metastasis (P=0.012), and disease-free survival (P=0.009). Higher CYPFRA 21-1 and CRP levels were also associated with higher risks of distant metastasis (log-rank test, P=0.013, (HR [95% CI]) 1.692 [1.097-2.414]).

conclusionsPreoperative CYFRA 21-1 and CRP levels are probable candidates as biomarkers for risk stratification in OSCC.

Indexed as

AdultAgedAged, 80 and overAntigens, NeoplasmBiomarkers, TumorCarcinoma, Squamous CellC-Reactive ProteinEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansKeratin-19Lymphatic MetastasisMaleMiddle AgedMouth Neoplasmsantigen CYFRA21.1Antigens, NeoplasmBiomarkers, TumorC-Reactive ProteinKeratin-19

Identifiers

PMID26292957
PMCPMC4546149
OpenAlexW2154272093

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.