ArticleNature communications2015
Ultrastructural and functional fate of recycled vesicles in hippocampal synapses.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed.
- Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI.Molecular neurobiology · 2026Article
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Lysophosphatidic acid selectively modulates excitatory transmission in hippocampal neurons.Cell & bioscience · 2025Article
- Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle.Science advances · 2025Article
- Tau-mediated synaptic dysfunction is coupled with HCN channelopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses.eLife · 2024Article
- SV2B defines a subpopulation of synaptic vesicles.Journal of molecular cell biology · 2024Article
- Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Nano-Organization at the Synapse: Segregation of Distinct Forms of Neurotransmission.Frontiers in synaptic neuroscience · 2021Review
- Misfolded amyloid-β-42 impairs the endosomal-lysosomal pathway.Cellular and molecular life sciences : CMLS · 2020Article
- Article
- Homeostatic Plasticity in Epilepsy.Frontiers in cellular neuroscience · 2020Article
- Encoding Temporal Regularities and Information Copying in Hippocampal Circuits.Scientific reports · 2019Article
- Sparse force-bearing bridges between neighboring synaptic vesicles.Brain structure & function · 2019Article
- Dedicated Setup for the Photoconversion of Fluorescent Dyes for Functional Electron Microscopy.Frontiers in cellular neuroscience · 2019Article
- Model-Based Inference of Synaptic Transmission.Frontiers in synaptic neuroscience · 2019Review
- Presynaptic origins of distinct modes of neurotransmitter release.Current opinion in neurobiology · 2018Review
- Homeostatic Presynaptic Plasticity Is Specifically Regulated by P/Q-type CaCell reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Efficient recycling of synaptic vesicles is thought to be critical for sustained information transfer at central terminals. However, the specific contribution that retrieved vesicles make to future transmission events remains unclear. Here we exploit fluorescence and time-stamped electron microscopy to track the functional and positional fate of vesicles endocytosed after readily releasable pool (RRP) stimulation in rat hippocampal synapses. We show that most vesicles are recovered near the active zone but subsequently take up random positions in the cluster, without preferential bias for future use. These vesicles non-selectively queue, advancing towards the release site with further stimulation in an actin-dependent manner. Nonetheless, the small subset of vesicles retrieved recently in the stimulus train persist nearer the active zone and exhibit more privileged use in the next RRP. Our findings reveal heterogeneity in vesicle fate based on nanoscale position and timing rules, providing new insights into the origins of future pool constitution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.