SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2015
Central venous pressure and liver resection: a systematic review and meta-analysis.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02954913 (Simultaneous RESEction of Colorectal Cancer With Synchronous Liver MeTastases), which is not on this map. Cited by 53 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Simultaneous RESEction of Colorectal Cancer With Synchronous Liver MeTastases (RESECT): A Feasibility Study
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Outcomes After Intraoperative Hypovolemic Phlebotomy in Patients Undergoing Liver Surgery: A Meta-Analysis.World journal of surgery · 2026Pooled it
- Application of cardiovascular interventions to decrease blood loss during hepatectomy: a systematic review and meta-analysis.BMC anesthesiology · 2023Pooled it
- Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022.World journal of surgery · 2023Pooled it
- Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations.World journal of surgery · 2016Pooled it
- Feasibility of using head up patient position in maintaining low central venous pressure and restricting the need for pharmacological agents during major hepatectomy.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Balancing safety and outcomes in minimally invasive liver resection: insights from the PRESSURE trial.Hepatobiliary surgery and nutrition · 2026Article
- Evaluating pneumoperitoneum pressure in robotic liver surgery: a propensity-score matched analysis in a high-volume center in Scandinavia.Surgical endoscopy · 2026Article
- Article
- Laparoscopic versus open secondary hepatectomy treating postoperative regional recurrent hepatolithiasis: a multicenter real-world study.Surgical endoscopy · 2025Article
- Acute kidney injury after major hepatectomy: association with postoperative complications and post-hepatectomy liver failure.BJS open · 2025Article
- Article
- Controlled low central venous pressure maintenance level during laparoscopic hepatectomy negatively associated with PHLF incidence: a retrospective propensity score matching study.Surgical endoscopy · 2025Article
- Low versus standard central venous pressure during laparoscopic liver resection: A systematic review, meta-analysis and trial sequential analysis.Annals of hepato-biliary-pancreatic surgery · 2024Review
- TAVAC: comprehensive review of currently available hemostatic products as adjunct to surgical hemostasis.Surgical endoscopy · 2024Review
- Measuring intraoperative anesthetic parameters during hepatectomy with inferior vena cava clamping.Langenbeck's archives of surgery · 2023Article
- Prediction of postoperative complications after hepatectomy with dynamic monitoring of central venous oxygen saturation.BMC surgery · 2023Article
- "Hooking method" for hepatic inflow control: a new approach for laparoscopic Pringle maneuver.World journal of surgical oncology · 2023Article
- Influence of Intraoperative Blood Loss on Tumor Recurrence after Surgical Resection in Hepatocellular Carcinoma.Journal of personalized medicine · 2023Article
- The Optimal Fluid Strategy Matters in Liver Surgery: A Retrospective Single Centre Analysis of 666 Consecutive Liver Resections.Journal of clinical medicine · 2023Article
- Effect of thoracic epidural anesthesia on postoperative outcome in major liver surgery: a retrospective cohort study.Langenbeck's archives of surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA liver resection under low central venous pressure (CVP) has become standard practice; however, the benefits beyond a reduction in blood loss are not well reported. Moreover, the precise method to achieve CVP reduction has not been established. A systematic review and meta-analysis of randomized controlled trials (RTCs) was performed to assess the effects of CVP on clinical outcome and to identify the optimum method of CVP reduction.
methodsEMBASE, Medline, PubMed and the Cochrane database were searched for trials comparing low CVP surgery with controls. The primary outcome was post-operative complications within 30 days. Secondary outcomes included estimated blood loss (EBL), blood transfusion rates and length of stay (LOS). Sub-group analysis was performed to assess the CVP reduction method on the outcome.
resultsEight trials were identified. No difference was observed in the morbidity rate between the high CVP and control groups [odds ratio (OR) = 0.96 (95% confidence interval (CI) 0.66, 1.40) P = 0.84, I(2) = 0%]. EBL [weighted mean difference (WMD) = -308.63 ml (95% CI -474.67, -142.58) P = < 0.001, I(2) = 73%] and blood transfusion rates [OR 0.65 (95% CI 0.44, 0.97) P = 0.040, I(2) = 37%] were significantly lower in the low CVP groups. Neither anaesthetic nor surgical methods of CVP reduction were associated with a reduced post-operative morbidity.
conclusionLow CVP surgery is associated with a reduction in EBL; however, this does not translate into an improvement in post-operative morbidity. The optimum method of CVP reduction has not been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.