ArticleJournal of neuroscience methods2015
Optimising a model-based approach to inferring fear learning from skin conductance responses.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Effects of doxycycline on intrusive experimental trauma memory: a pre-registered, randomized double-blind placebo-controlled trial.Translational psychiatry · 2026Trial
- The Effect of Suvorexant on Fear Extinction Recall: A Double-Blind Randomised Controlled Pilot Trial in Healthy Individuals.Journal of sleep research · 2025Trial
- The impact of doxycycline on human contextual fear memory.Psychopharmacology · 2024Trial
- Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory.eNeuro · 2023Trial
- Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline.Molecular psychiatry · 2018Trial
- Prazosin during threat discrimination boosts memory of the safe stimulus.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Trial
- Experiment-based calibration: Inference and decision-making.Behavior research methods · 2026Article
- Psychophysiological Outcome Responses in Human Pavlovian Fear Conditioning: A Prediction Error Analysis.Psychophysiology · 2026Article
- Are you afraid? Neurophysiological responses to multidimensional fear in an interactive semi-immersive environment.Frontiers in systems neuroscience · 2026Article
- Autonomic Disequilibrium at Rest in Autistic Children and Adults.Applied psychophysiology and biofeedback · 2025Article
- EzySCR: A free and easy tool for scoring event-related skin conductance responses in the first, second, and third interval latency windows.Psychophysiology · 2024Article
- Dimensionality and optimal combination of autonomic fear-conditioning measures in humans.Behavior research methods · 2024Article
- Measuring human context fear conditioning and retention after consolidation.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning.Mental health and physical activity · 2023Article
- Atypical Response to Affective Touch in Children with Autism: Multi-Parametric Exploration of the Autonomic System.Journal of clinical medicine · 2022Article
- Measuring human trace fear conditioning.Psychophysiology · 2022Article
- Article
- Misophonia: Analysis of the neuroanatomic patterns at the basis of psychiatric symptoms and changes of the orthosympathetic/ parasympathetic balance.Frontiers in neuroscience · 2022Article
- Saccadic scanpath length: an index for human threat conditioning.Behavior research methods · 2021Article
- Theta oscillations synchronize human medial prefrontal cortex and amygdala during fear learning.Science advances · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Anticipatory sympathetic arousal is often inferred from skin conductance responses (SCR) and used to quantify fear learning. We have previously provided a model-based approach for this inference, based on a quantitative Psychophysiological Model (PsPM) formulated in non-linear dynamic equations. Here we seek to optimise the inversion of this PsPM. Using two independent fear conditioning datasets, we benchmark predictive validity as the sensitivity to separate the likely presence or absence of the unconditioned stimulus. Predictive validity is optimised across both datasets by (a) using a canonical form of the SCR shape (b) filtering the signal with a bi-directional band-pass filter with cut off frequencies 0.0159 and 5 Hz, (c) simultaneously inverting two trials (d) explicitly modelling skin conductance level changes between trials (e) the choice of the inversion algorithm (f) z-scoring estimates of anticipatory sympathetic arousal from each participant across trials. The original model-based method has higher predictive validity than conventional peak-scoring or an alternative model-based method (Ledalab), and benefits from constraining the model, optimised data preconditioning, and post-processing of ensuing parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.