Evidence map›Paper›PMID 26291823›Full record

ArticlePloS one2015

Fish-Free Diet in Patients with Phenylketonuria Is Not Associated with Early Atherosclerotic Changes and Enhanced Platelet Activation.

Patrik Htun, Jens Nee, Ursula Ploeckinger, Klaus Eder, Tobias Geisler, Meinrad Gawaz, Wolfgang Bocksch, Suzanne Fateh-Moghadam

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04251494 (An Observational, Cross-sectional Study Into the Future Cardiovascular Disease), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04251494 unknown statusnot on this mapstarted 2019, after this paper: background citation

An Observational, Cross-sectional Study Into the Future Cardiovascular Disease (CVD) Risk of Phenylketonuria (PKU) Patients on a Low Phenylalanine Treatment Diet (LPD).

TypeobservationalSponsorGuy's and St Thomas' NHS Foundation TrustRan2019 to 2021Enrolled32ConditionsPhenylketonurias, Cardiovascular DiseasesArmsCarotid intima media thickness measurement (CIMT), Pulse Wave Velocity measurement, Ankle-brachial pressure index (ABPI), Diet questionnaire and diet diary, Routine blood samples
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Patrik HtunZentrale Notaufnahme und Medizinische Klinik IV, Zentralklinikum Augsburg, Germany.
Jens NeeMedizinische Klinik mit Schwerpunkt Nephrologie und Intensivmedizin, Charite-Universitaetsmedizin Campus Virchow-Klinikum, Humboldt-Universitaet zu Berlin, Germany.
Ursula PloeckingerInterdisziplinaeres Stoffwechsel-Centrum, Charite-Universitaetsmedizin Campus Virchow-Klinikum, Humboldt-Universitaet zu Berlin, Germany.
Klaus EderInstitut für Tierernährung und Ernährungsphysiologie, Justus-Liebig-Universität Giessen, Germany.
Tobias GeislerMedizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universitaet Tuebingen, Germany.
Meinrad GawazMedizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universitaet Tuebingen, Germany.
Wolfgang BockschMedizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universitaet Tuebingen, Germany.
Suzanne Fateh-MoghadamMedizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universitaet Tuebingen, Germany.
University of Tübingen · DEHumboldt-Universität zu Berlin · DEUniversity Hospital Augsburg · DEUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSince patients with phenylketonuria (PKU) have to follow a lifelong restriction of natural protein to lower phenylalanine-intake, they never eat fish. This diet may lead to a chronic deficit of omega-3 and omega-6 fatty acids with the risk of early atherosclerotic changes. The aim of the study was to analyse the fatty acid profile of PKU patients and to correlate the results with surrogate markers of early atherosclerotic changes [enhanced carotid intima media thickness (CIMT) and ß-stiffness index] and platelet activation.

methodsIn 43 PKU patients and in 58 healthy controls we prospectively examined the fatty acid profile, CIMT, ß-stiffness index and platelet activation (flow cytometric determination of markers of platelet activation). CIMT was measured bilaterally by ultrasound. CIMTmean was defined as the mean value of the sum of CIMTleft and CIMTright.

resultsDespite of lower HDL-cholesterol and higher triglyceride concentrations in the PKU group, there was no significant difference in the omega-6 or omega-3 fatty acid profile, CIMT, ß-stiffness index between both groups. Platelet activation was not enhanced in the PKU group.

conclusionsFish-free diet does not induce early atherosclerotic changes or enhanced platelet activation in PKU patients.

Indexed as

FishesAdultAnimalsAtherosclerosisCarotid Intima-Media ThicknessCase-Control StudiesCholesterol, HDLDiet, Protein-RestrictedFatty AcidsFemaleFlow CytometryHumansMalePhenylketonuriasPlatelet ActivationTriglyceridesCholesterol, HDLFatty AcidsTriglycerides

Identifiers

PMID26291823
PMCPMC4546235
OpenAlexW1814307983

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.