Evidence map›Paper›PMID 26291793›Full record

ArticlePLoS genetics2015

Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference.

Lucy van Dorp, David Balding, Simon Myers, Luca Pagani, Chris Tyler-Smith, Endashaw Bekele, Ayele Tarekegn, Mark G Thomas, Neil Bradman, Garrett Hellenthal

Open access · goldAbstract read
In one paragraph

Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 249 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Methods for Assessing Population Relationships and History Using Genomic Data.Annual review of genomics and human genetics · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Sometimes hidden but always there: the assumptions underlying genetic inference of demographic histories.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Lucy van DorpUniversity College London Genetics Institute (UGI), University College London, London, United Kingdom; Centre for Mathematics and Physics in the Life Sciences and EXperimental Biology (CoMPLEX), University College London, London, United Kingdom.
David BaldingUniversity College London Genetics Institute (UGI), University College London, London, United Kingdom; Schools of BioSciences and of Mathematics & Statistics, University of Melbourne, Melbourne, Australia.
Simon MyersDepartment of Statistics, University of Oxford, Oxford, United Kingdom.
Luca PaganiThe Wellcome Trust Sanger Institute, Hinxton, United Kingdom; Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom.
Chris Tyler-SmithThe Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Endashaw BekeleAddis Ababa University, Addis Ababa, Ethiopia.
Ayele TarekegnHenry Stewart Group, London, United Kingdom.
Mark G ThomasResearch Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Neil BradmanHenry Stewart Group, London, United Kingdom.
Garrett HellenthalUniversity College London Genetics Institute (UGI), University College London, London, United Kingdom.
University College London · GBAddis Ababa University · ETUniversity of Cambridge · GBUniversity of Oxford · GBWellcome Sanger Institute · GB

Funding

Wellcome Trust 098051Wellcome Trust 098386Wellcome Trust 098386/Z/12/ZWellcome Trust 098387/Z/12/Z
6 · The paper itself

Abstract

The Ari peoples of Ethiopia are comprised of different occupational groups that can be distinguished genetically, with Ari Cultivators and the socially marginalised Ari Blacksmiths recently shown to have a similar level of genetic differentiation between them (FST ≈ 0.023 - 0.04) as that observed among multiple ethnic groups sampled throughout Ethiopia. Anthropologists have proposed two competing theories to explain the origins of the Ari Blacksmiths as (i) remnants of a population that inhabited Ethiopia prior to the arrival of agriculturists (e.g. Cultivators), or (ii) relatively recently related to the Cultivators but presently marginalized in the community due to their trade. Two recent studies by different groups analysed genome-wide DNA from samples of Ari Blacksmiths and Cultivators and suggested that genetic patterns between the two groups were more consistent with model (i) and subsequent assimilation of the indigenous peoples into the expanding agriculturalist community. We analysed the same samples using approaches designed to attenuate signals of genetic differentiation that are attributable to allelic drift within a population. By doing so, we provide evidence that the genetic differences between Ari Blacksmiths and Cultivators can be entirely explained by bottleneck effects consistent with hypothesis (ii). This finding serves as both a cautionary tale about interpreting results from unsupervised clustering algorithms, and suggests that social constructions are contributing directly to genetic differentiation over a relatively short time period among previously genetically similar groups.

Indexed as

AllelesCluster AnalysisCultureEthiopiaEthnicityGenetic DriftGenetics, MedicalHumans

Identifiers

PMID26291793
PMCPMC4546361
OpenAlexW1804243006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.