ArticleNeurology2015
Acute headache diagnosis in pregnant women: a hospital-based study.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03951649 (Acute Headache Treatment in Pregnancy), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Headache and pregnancy: a systematic review.The journal of headache and pain · 2017Pooled it
- Sex-specific considerations in migraine therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Neurologic Complications of Pregnancy and Menopause.Continuum (Minneapolis, Minn.) · 2026Review
- "NÃO É PRIMÁRIA": a Portuguese version of the SNNOOP10 mnemonic.Arquivos de neuro-psiquiatria · 2025Article
- Increased prevalence of transient visual disturbances with normal ocular exam findings in pregnancy - cross-sectional study.Scientific reports · 2025Article
- Pineal cyst apoplexy in a pregnant female: case report and review of literature.BMC neurology · 2025Review
- Thunderclap headache as a first manifestation of acute disseminated encephalomyelitis: case report and literature review.BMC neurology · 2024Review
- Management of an acute intracranial emergency in pregnancy.BMJ case reports · 2024Article
- How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review.Journal of personalized medicine · 2024Review
- Prevalence and course of pregnancy symptoms using self-reported pregnancy app symptom tracker data.NPJ digital medicine · 2023Article
- Neurologic Consultations and Headache during Pregnancy and in Puerperium: A Retrospective Chart Review.Journal of clinical medicine · 2023Article
- Secondary headaches in pregnancy and the puerperium.Frontiers in neurology · 2023Review
- Pineal Apoplexy Presenting With Recurrent Migraine-Like Headache and Transitory Neurological Dysfunction During Pregnancy.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Medulloblastoma Presenting as Severe Headache during Pregnancy: A Case Report and Review of the Literature.Medicina (Kaunas, Lithuania) · 2022Review
- Headache as a Neurologic Manifestation of Systemic Disease.Current treatment options in neurology · 2022Review
- MRI in Pregnancy and Precision Medicine: A Review from Literature.Journal of personalized medicine · 2021Review
- Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.Current pain and headache reports · 2021Review
- Article
- Neurovascular disorders in pregnancy: A review.Obstetric medicine · 2019Review
- Neurological manifestations and neuroimaging presentations in patients with severe preeclampsia: predisposing factors and clinical implications.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize demographic and clinical features in pregnant women presenting with acute headache, and to identify clinical features associated with secondary headache.
methodsWe conducted a 5-year, single-center, retrospective study of consecutive pregnant women presenting to acute care with headache receiving neurologic consultation.
resultsThe 140 women had a mean age of 29 ± 6.4 years and often presented in the third trimester (56.4%). Diagnoses were divided into primary (65.0%) and secondary (35.0%) disorders. The most common primary headache disorder was migraine (91.2%) and secondary headache disorders were hypertensive disorders (51.0%). The groups were similar in demographics, gestational ages, and most headache features. In univariate analysis, secondary headaches were associated with a lack of headache history (36.7% vs 13.2%, p = 0.0012), seizures (12.2% vs 0.0%, p = 0.0015), elevated blood pressure (55.1% vs 8.8%, p < 0.0001), fever (8.2% vs 0.0%, p = 0.014), and an abnormal neurologic examination (34.7% vs 16.5%, p = 0.014). In multivariate logistic regression, elevated blood pressure (odds ratio [OR] 17.0, 95% confidence interval [CI] 4.2-56.0) and a lack of headache history (OR 4.9, 95% CI 1.7-14.5) had an increased association with secondary headache, while psychiatric comorbidity (OR 0.13, 95% CI 0.021-0.78) and phonophobia (OR 0.29, 95% CI 0.09-0.91) had a reduced association with secondary headache.
conclusionsAmong pregnant women receiving inpatient neurologic consultation, more than one-third have secondary headache. Diagnostic vigilance should be heightened in the absence of a headache history and if seizures, hypertension, or fever are present. Attack features may not adequately distinguish primary vs secondary disorders, and low thresholds for neuroimaging and monitoring for preeclampsia are justified.
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