ArticleNeuron2015
Unravelling Spinal Circuits of Pain and Mechanical Allodynia.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats.Molecular neurobiology · 2021Article
- Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.Scientific reports · 2019Article
- Contribution of Loss of Large Fiber Function to Pain in 2 Samples of Oncology Patients.The Clinical journal of pain · 2019Article
- Involvement of Neuropeptide Y in Post-Incisional Nociception in Rats.Annals of neurosciences · 2018Article
- Structural plasticity and reorganisation in chronic pain.Nature reviews. Neuroscience · 2016Review
- Differing roles for parvalbumin neurons after nerve injury.Neural regeneration research · 2016Article
- Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current ( IMolecular painArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.