ArticleVeterinary clinical pathology2015
Dog erythrocyte antigen 1: mode of inheritance and initial characterization.
Article in Veterinary clinical pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Prevalence of Dal blood type and dog erythrocyte antigens 1 and 4 among canine blood donors and recipients in Seoul, South Korea.BMC veterinary research · 2025Article
- Evaluation of Canine Erythrocyte Surface Antigens and Morphological Alterations Induced by Trypsin Treatment.Animals : an open access journal from MDPI · 2025Article
- Frequency of erythrocyte antigen DEA 1 expression in dogs (Open veterinary journal · 2025Article
- Dog Blood Type DEA 1 in Two Municipalities of Luanda Province of Angola (Sub-Saharan Africa).Veterinary sciences · 2024Article
- Canine Blood Group Prevalence and Geographical Distribution around the World: An Updated Systematic Review.Animals : an open access journal from MDPI · 2021Review
- The dog erythrocyte antigen 1 blood group in nondomesticated canids and compatibility testing between domestic dog and nondomesticated canid blood.Journal of veterinary internal medicine · 2020Article
- Survey of Blood GroupsFrontiers in veterinary science · 2020Article
- Alloimmunization of a dog erythrocyte antigen 1- dog transfused with weakly dog erythrocyte antigen 1+ blood.Journal of veterinary internal medicine · 2019Article
- Frequency of DEA 1 antigen in 1037 mongrel and PUREBREED dogs in ITALY.BMC veterinary research · 2017Article
- Pre- and Post-Transfusion Alloimmunization in Dogs Characterized by 2 Antiglobulin-Enhanced Cross-match Tests.Journal of veterinary internal medicine · 2017Article
- Prevalence and Mode of Inheritance of the Dal Blood Group in Dogs in North America.Journal of veterinary internal medicine · 2017Article
- Prevalence of Dog Erythrocyte Antigen 1 in 7,414 Dogs in Italy.Veterinary medicine international · 2017Article
- Kai 1 and Kai 2: Characterization of these dog erythrocyte antigens by monoclonal antibodies.PloS one · 2017Article
- Survey of Two New (Kai 1 and Kai 2) and Other Blood Groups in Dogs of North America.Journal of veterinary internal medicine · 2016Article
- Letter regarding "Validation of a cage-side agglutination card for Dal blood typing in dogs" - Validation of agglutination card kit or simple comparison to gel column method for canine Dal blood typing?Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe dog erythrocyte antigen (DEA) 1 blood group system remains poorly defined.
objectivesThe purpose of the study was to determine the DEA 1 mode of inheritance and to characterize the DEA 1 antigen and alloantibodies. ANIMALS: Canine research colony families, clinic canine patients, and DEA 1.2+ blood bank dogs were studied.
methodsCanine blood was typed by flow cytometry and immunochromatographic strips using anti-DEA 1 monoclonal antibodies. Gel column experiments with polyclonal and immunoblotting with monoclonal anti-DEA 1 antibodies were performed to analyze select samples. Cross-reactivity of human typing reagents against canine RBC and one monoclonal anti-DEA 1 antibody against human RBC panels was assessed.
resultsTyping of 12 families comprising 144 dogs indicated an autosomal dominant inheritance with ≥ 4 alleles: DEA 1- (0) and DEA 1+ weak (1+), intermediate (2+), and strong (3+ and 4+). Samples from 6 dogs previously typed as DEA 1.2+ were typed as DEA 1+ or DEA 1- using monoclonal antibodies. Human typing reagents produced varied reactions in tube agglutination experiments against DEA 1+ and DEA 1- RBC. Polypeptide bands were not detected on immunoblots using a monoclonal anti-DEA 1 antibody, therefore the anti-DEA 1 antibody may be specific for conformational epitopes lost during processing.
conclusionsThe autosomal dominant inheritance of DEA 1 with ≥ 4 alleles indicates a complex blood group system; the antigenicity of each DEA 1+ type will need to be determined. The biochemical nature of the DEA 1 antigen(s) appears different from human blood group systems tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.