ArticleThe journal of physical chemistry letters2012
Local Lipid Reorganization by a Transmembrane Protein Domain.
Article in The journal of physical chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- PIP2 regulation of TRPV4 channels: Binding sites and dynamic coupling.Biophysical journal · 2025Article
- Molecular Biophysics of Class A G Protein Coupled Receptors-Lipids Interactome at a Glance-Highlights from the ABiomolecules · 2023Review
- Regulation of Membrane Calcium Transport Proteins by the Surrounding Lipid Environment.Biomolecules · 2019Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Emerging Diversity in Lipid-Protein Interactions.Chemical reviews · 2019Review
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations.The Journal of membrane biology · 2017Article
- The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)PPhysical chemistry chemical physics : PCCP · 2016Article
- Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.Biochimica et biophysica acta · 2016Review
- Membrane Compartmentalization Reducing the Mobility of Lipids and Proteins within a Model Plasma Membrane.The journal of physical chemistry. B · 2016Article
- Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor.The journal of physical chemistry. B · 2016Article
- Organization and Dynamics of Receptor Proteins in a Plasma Membrane.Journal of the American Chemical Society · 2015Article
- Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations.Biochimica et biophysica acta · 2015Article
- Annular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex.The Journal of biological chemistry · 2015Article
- The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids.Scientific reports · 2015Article
- Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin.PLoS computational biology · 2015Article
- Lipid clustering correlates with membrane curvature as revealed by molecular simulations of complex lipid bilayers.PLoS computational biology · 2014Article
- Primary and secondary dimer interfaces of the fibroblast growth factor receptor 3 transmembrane domain: characterization via multiscale molecular dynamics simulations.Biochemistry · 2014Article
- How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.Frontiers in pharmacology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Membrane proteins interact with their lipid bilayer environment via both a transmembrane helix and juxtamembrane regions. The effect of juxtamembrane regions and membrane lipid composition on these interactions has been explored by multiscale molecular dynamics simulations. The consequences of anionic lipids within the inner leaflet of a membrane were studied in combination with membrane spanning protein models differing in their juxtamembrane domains. The simulations reveal sensitivity of the protein-lipid interactions to membrane lipid composition and charged amino acid side chains. Basic residues on the intracellular side of the protein facilitated interactions with anionic lipids. Protein systems without basic residues do not show selectivity for anionic compared with zwitterionic lipids. This reveals the sensitivity to the composition of both the membrane and the protein system when studying membrane-embedded proteins. The results presented here illustrate how even a simple transmembrane domain is able to induce lipid reorganization in a mixed asymmetric bilayer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.