ArticleJournal of diabetes research2015
Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China.
Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Association of Genetic Variants ofInternational journal of endocrinology · 2026Article
- New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.BMJ open ophthalmology · 2025Article
- Corneal characteristics of Mongolian population with type 2 diabetic peripheral neuropathy in inner Mongolia, China: an assessment using corneal confocal microscopy.BMC ophthalmology · 2023Article
- Medical Genetics, Genomics and Bioinformatics-2022.International journal of molecular sciences · 2023Article
- Editorial: Population and ancestry specific variation in disease susceptibility.Frontiers in genetics · 2023Article
- Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.PloS one · 2023Article
- Identification of a Trm732 Motif Required for 2'-ACS omega · 2022Article
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- Editorial: Association Between Individuals' Genomic Ancestry and Variation in Disease Susceptibility.Frontiers in genetics · 2022Article
- Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3.Cancer research · 2021Article
- Transmembrane 163 (TMEM163) Protein: A New Member of the Zinc Efflux Transporter Family.Biomedicines · 2021Review
- Medical genetics studies at the SBB-2019 and MGNGS-2019 conferences.BMC medical genetics · 2020Article
- Genetics research at the "Centenary of human population genetics" conference and SBB-2019.BMC genetics · 2020Article
- Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.Journal of diabetes research · 2020Article
- BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases.Bioscience reports · 2019Review
- Prevalence of and risk factors for refractive error: a cross-sectional study in Han and Mongolian adults aged 40-80 years in Inner Mongolia, China.Eye (London, England) · 2019Article
- Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies.Journal of veterinary internal medicine · 2019Article
- A variant in KCNQ1 gene predicts metabolic syndrome among northern urban Han Chinese women.BMC medical genetics · 2018Article
- The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women.The Journal of international medical research · 2018Article
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The large scale genome wide association studies (GWAS) have identified approximately 80 single nucleotide polymorphisms (SNPs) conferring susceptibility to type 2 diabetes (T2D). However, most of these loci have not been replicated in diverse populations and much genetic heterogeneity has been observed across ethnic groups. We tested 28 SNPs previously found to be associated with T2D by GWAS in a Mongolian sample of Northern China (497 diagnosed with T2D and 469 controls) for association with T2D and diabetes related quantitative traits. We replicated T2D association of 11 SNPs, namely, rs7578326 (IRS1), rs1531343 (HMGA2), rs8042680 (PRC1), rs7578597 (THADA), rs1333051 (CDKN2), rs6723108 (TMEM163), rs163182 and rs2237897 (KCNQ1), rs1387153 (MTNR1B), rs243021 (BCL11A), and rs10229583 (PAX4) in our sample. Further, we showed that risk allele of the strongest T2D associated SNP in our sample, rs757832 (IRS1), is associated with increased level of TG. We observed substantial difference of T2D risk allele frequency between the Mongolian sample and the 1000G Caucasian sample for a few SNPs, including rs6723108 (TMEM163) whose risk allele reaches near fixation in the Mongolian sample. Further study of genetic architecture of these variants in susceptibility of T2D is needed to understand the role of these variants in heterogeneous populations.
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