Trial reportBioMed research international2015
Lower Urinary Tract Symptoms Are Associated with Increased Risk of Dementia among the Elderly: A Nationwide Study.
Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- The effect of oral medications on fMRI brain activation: A randomized, double blind, controlled pilot trial of older women with overactive bladder.International urogynecology journal · 2023Trial
- Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the REGARDS Cohort Study.Journal of the American Geriatrics Society · 2026Article
- Limited Predictive Value of Urodynamic Studies for Postmicturition Dribbling in Surgery-Naive Men With Lower Urinary Tract Symptoms.International neurourology journal · 2026Article
- Finding risk factors for dementia in patients with schizophrenia: a population-based case-control study.BMC psychiatry · 2026Article
- Incidence of Dementia Among Medicare Beneficiaries With and Without Urinary Incontinence.Urogynecology (Philadelphia, Pa.) · 2025Article
- Lower Urinary Tract Symptoms and Fall Risk: An Important Problem in Older Women with Cognitive Frailty.International urogynecology journal · 2025Article
- Risk of Developing Alzheimer Disease in Relation to Common Infections.Neuro-degenerative diseases · 2025Article
- Article
- Longitudinal study of cognitive decline among women with and without urinary incontinence.American journal of obstetrics and gynecology · 2024Article
- The Need for Prospective Cohort Study of the Association between Lower Urinary Tract Symptoms and Cognitive Decline in Elderly Individuals.The world journal of men's health · 2023Article
- The association between acupuncture therapy and the risk of reduced pressure ulcers in dementia patients: A retrospective matched cohort study.Integrative medicine research · 2023Article
- Voiding Dysfunction Due to Urethral Sphincter Dysfunction Might Be an Early Neurological Presentation of Central Nervous System Disorders in Aged Patients.Journal of personalized medicine · 2023Article
- Lower Urinary Tract Symptoms in Depression: A Review.Health psychology research · 2023Article
- Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations.Nature communications · 2022Article
- Urinary dysfunction in patients with vascular cognitive impairment.Frontiers in aging neuroscience · 2022Review
- The cognitive effect of anticholinergics for patients with overactive bladder.Nature reviews. Urology · 2021Review
- Triple-disease etiology is common for LUTS in octogenarians: a neuro-urological approach.International urology and nephrology · 2021Article
- The Impact of Illness Perceptions on Depressive Symptoms Among Benign Prostatic Hyperplasia Patients with Lower Urinary Tract Symptom.International journal of general medicine · 2021Article
- Protocol for a multicenter randomized, double blind, controlled pilot trial of higher neural function in overactive bladder patients after anticholinergic, beta-3 adrenergic agonist, or placebo.Contemporary clinical trials communications · 2020Article
- Cumulative use of therapeutic bladder anticholinergics and the risk of dementia in patients with lower urinary tract symptoms: a nationwide 12-year cohort study.BMC geriatrics · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies show a strong association between dementia and lower urinary tract symptoms (LUTS). The aim of this study was to investigate whether LUTS are a risk factor for cognitive impairment. We enrolled 50-year-old and older subjects with LUTS (LUTS([+])) (n = 6801) and controls without LUTS (LUTS([-])) (n = 20,403) from Taiwan's National Health Insurance Research Database. LUTS, dementia, and other confounding factors are defined by International Classification of Diseases, Ninth Revision, Clinical Modification Codes. Participants were recruited from 2000 to 2004 and then followed up until death or the end of 2011. The outcome was the onset of dementia, which was assessed using Poisson regression analysis, Cox hazards models, and Kaplan-Meier survival curves. The incidence of dementia was significantly higher in the LUTS([+]) group than in the LUTS([-]) group (124.76 versus 77.59/1000 person-years). The increased risk of dementia related to LUTS remained significant after adjustment for potential confounders (adjusted hazard ratio (AHR): 1.61, 95% confidence interval (CI) 1.47-1.76, P < 0.0001) and higher than that related to cerebrovascular disease (AHR: 1.43, 95% CI 1.26-1.61, P < 0.0001). The outcome suggests the need for early screening and appropriate intervention to help prevent cognitive impairment of patients with LUTS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.