Evidence map›Paper›PMID 26290633›Full record

ArticleWorld journal of gastroenterology2015

Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions.

Yukihito Ishii, Yu Motohashi, Makoto Muramatsu, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Takahisa Yamada, Tohru Matsui, Shinichi Kume, Takeshi Ohta

Open access · hybridAbstract readComparative Study

PubMed Full text at PMC Publisher

In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

1.5field-weighted citation impact, top 18% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

Glomerular hyperfiltration with hyperglycemia in the spontaneously diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model.Physiological research · 2021
Article
Characteristics of bile acid composition in high fat diet-induced nonalcoholic fatty liver disease in obese diabetic rats.PloS one · 2021
Article
Teriparatide Improves Bone and Lipid Metabolism in a Male Rat Model of Type 2 Diabetes Mellitus.Endocrinology · 2019
Article
Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-LeprThe Journal of veterinary medical science · 2018
Article
Determination of peripheral neuropathy in high-fat diet fed low-dose streptozotocin-treated female C57Bl/6J mice and Sprague-Dawley rats.Journal of diabetes investigation · 2018
Article
Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.The Journal of veterinary medical science · 2018
Article
Pathophysiological Features of Rat Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis.In vivo (Athens, Greece)
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yukihito IshiiYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Yu MotohashiYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Makoto MuramatsuYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Yoshiaki KatsudaYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Katsuhiro MiyajimaYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Tomohiko SasaseYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Takahisa YamadaYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Tohru MatsuiYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Shinichi KumeYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Takeshi OhtaYukihito Ishii, Makoto Muramatsu, Yoshiaki Katsuda, Tomohiko Sasase, Takeshi Ohta, Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka 569-1125, Japan.

Japan Tobacco (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the histological features of the liver in spontaneously diabetic Torii (SDT) fatty rats compared with age-matched Sprague-Dawley (SD) rats.

methodsFemale SDT Lepr(fa) (SDT fatty) rats and age-matched SD rats were fed ad libitum. Body weight and biochemical parameters, such as serum glucose, triglyceride (TG), total cholesterol (TC), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels as well as fatty acid and TG accumulation in the liver were evaluated at 8 wk of age in the non-fasting state and at 8-wk intervals from 8 to 40 wk of age. Histopathological examinations of the liver were performed using hematoxylin and eosin and Sirius Red staining as well as double staining for ED-1 and toluidine blue. The expression of genes involved in TG synthesis, inflammation, and fibrosis was examined in the liver.

resultsSDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose, TG, and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically, severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age, and fibrosis started to occur at 32 wk of age. Furthermore, Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis, inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats, and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats.

conclusionFemale SDT fatty rats have the potential to become an important animal model of nonalcoholic steatohepatitis with type 2 diabetes and obesity.

Indexed as

Age FactorsAlanine TransaminaseAnimalsAspartate AminotransferasesBiomarkersBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalFemaleGene Expression RegulationLipidsLiverLiver Cirrhosis, ExperimentalNon-alcoholic Fatty Liver DiseaseObesityRats, Inbred StrainsAlanine TransaminaseAspartate AminotransferasesBiomarkersBlood GlucoseLipidsRNA, MessengerFatty liverFibrosisMetabolic syndromeNonalcoholic steatohepatitisSpontaneously diabetic Torii fatty rat

Identifiers

PMID26290633

DOI10.3748/wjg.v21.i30.9067

PMCPMC4533038

OpenAlexW1146759490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.