Evidence map›Paper›PMID 26290449›Full record

ArticleEpilepsia2015

Resting-state functional connectivity in the baboon model of genetic generalized epilepsy.

Felipe S Salinas, C Ákos Szabó

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Neuroimaging in the Epileptic Baboon.Frontiers in veterinary science · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Felipe S SalinasResearch Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, U.S.A.
C Ákos SzabóDepartment of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, U.S.A.
The University of Texas Health Science Center at San Antonio · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
EXTRAMURAL RES FACILITIES CONSTRC06RR015456 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 2001 to 2001
$1.1M
Brain MRI and Histopathology of the Epileptic BaboonR21NS084198 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SZABO, CHARLES AKOS · 2014 to 2015
$411k
Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in BaboonsR21NS065431 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SZABO, CHARLES AKOS · 2009 to 2010
$408k
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
BABOON F-CAGE FACILITY FOR PRIMATE RESEARCH CENTERC06RR014578 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1999 to 1999
–
NCRR NIH HHS C06 RR013556NCRR NIH HHS C06-RR013556NCRR NIH HHS C06 RR014578NCRR NIH HHS C06-RR014578NCRR NIH HHS C06 RR015456NCRR NIH HHS C06-RR015456NIH HHS P51 OD011133NINDS NIH HHS R21 NS065431NINDS NIH HHS R21-NS065431NINDS NIH HHS R21 NS084198NINDS NIH HHS R21-NS084198
6 · The paper itself

Abstract

objectiveThe baboon provides a natural model of genetic generalized epilepsy (GGE). This study compares the intrinsic connectivity networks of epileptic and healthy control baboons using resting-state functional magnetic resonance imaging (rs-fMRI) and data-driven functional connectivity mapping.

methodsTwenty baboons, matched for gender, age, and weight, were classified into two groups (10 epileptic [EPI], 10 control [CTL]) on the basis of scalp electroencephalography (EEG) findings. Each animal underwent one MRI session that acquired one 5-min resting state fMRI scan and one anatomic MRI scan-used for registration and spatial normalization. Using independent component analysis, we identified 14 unique components/networks, which were then used to characterize each group's functional connectivity maps of each brain network.

resultsThe epileptic group demonstrated network-specific differences in functional connectivity when compared to the control animals. The sensitivity and specificity of the two groups' functional connectivity maps differed significantly in the visual, motor, amygdala, insular, and default mode networks. Significant increases were found in the occipital gyri of the epileptic group's functional connectivity map for the default mode, cingulate, intraparietal, motor, visual, amygdala, and thalamic regions. SIGNIFICANCE: This is the first study using resting-state fMRI to demonstrate intrinsic functional connectivity differences between epileptic and control nonhuman primates. These results are consistent with seed-based GGE studies in humans; however, our use of a data-driven approach expands the scope of functional connectivity mapping to include brain regions/networks comprising the whole brain.

Indexed as

Epilepsy, GeneralizedRestAnimalsBrainDisease Models, AnimalImage Processing, Computer-AssistedMagnetic Resonance ImagingNeural PathwaysOxygenPapioOxygenFunctional connectivityGenetic generalized epilepsyNonhuman primatesResting-state fMRI

Identifiers

PMID26290449
PMCPMC4593742
OpenAlexW2099500577

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.