ArticleEuropean journal of nuclear medicine and molecular imaging2016
Characterization of age/sex and the regional distribution of mGluR5 availability in the healthy human brain measured by high-resolution [(11)C]ABP688 PET.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures.Translational psychiatry · 2025Pooled it
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- Organization of neuropeptide systems in the human brain.Nature neuroscience · 2026Article
- Metabotropic glutamate receptor 5 in the anterior cingulate cortex predicts individual differences in motor impulsivity but not in risky decision-making.Translational psychiatry · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Controlling the human connectome with spatially diffuse input signals.Communications biology · 2026Article
- An Interactive Brain Atlas of Knowledge.bioRxiv : the preprint server for biology · 2026Article
- Inter-individual variability of neurotransmitter receptor and transporter density in the human brain.Brain structure & function · 2026Article
- Neural correlates of distance-related functional reorganization in obsessive compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex.Human brain mapping · 2025Article
- Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder.Science advances · 2025Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Two subtypes of major depressive disorder are identified from individualized gray matter morphological abnormalities in a large multi-site dataset.Psychological medicine · 2025Article
- Network spreading and local biological vulnerability in amyotrophic lateral sclerosis.Communications biology · 2025Article
- Molecular-Informed Network Analysis Unveils Fatigue-Related Functional Connectivity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI.Communications biology · 2025Article
- Benchmarking methods for mapping functional connectivity in the brain.Nature methods · 2025Article
- Learning a Foreign Language in Older Adults Shapes the Functional Connectivity of Distinct Cerebellar Sub-Regions With Cortical Areas Rich in CBBrain and behavior · 2025Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
purposeMetabotropic glutamate receptor type 5 (mGluR5) is a G protein-coupled receptor that has been implicated in several psychiatric and neurological diseases. The radiopharmaceutical [(11)C]ABP688 allows for in vivo quantification of mGluR5 availability using positron emission tomography (PET). In this study, we aimed to detail the regional distribution of [(11)C]ABP688 binding potential (BPND) and the existence of age/sex effects in healthy individuals.
methodsThirty-one healthy individuals aged 20 to 77 years (men, n = 18, 45.3 ± 18.2 years; females, n = 13, 41.5 ± 19.6 years) underwent imaging with [(11)C]ABP688 using the high-resolution research tomograph (HRRT). We developed an advanced partial volume correction (PVC) method using surface-based analysis in order to accurately estimate the regional variation of radioactivity. BPND was calculated using the simplified reference tissue model, with the cerebellum as the reference region. Surface-based and volume-based analyses were performed for 39 cortical and subcortical regions of interest per hemisphere.
resultsWe found the highest [(11)C]ABP688 BPND in the lateral prefrontal and anterior cingulate cortices. The lowest [(11)C]ABP688 BPND was observed in the pre- and post-central gyri as well as the occipital lobes and the thalami. No sex effect was observed. Associations between age and [(11)C]ABP688 BPND without PVC were observed in the right amygdala and left putamen, but were not significant after multiple comparisons correction.
conclusionsThe present results highlight complexities underlying brain adaptations during the aging process, and support the notion that certain aspects of neurotransmission remain stable during the adult life span.
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