ArticleAutism research : official journal of the International Society for Autism Research2016
Cortical and subcortical glutathione levels in adults with autism spectrum disorder.
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Article in Autism research : official journal of the International Society for Autism Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.Early intervention in psychiatry · 2020Pooled it
- Using combined ROC curves to improve the diagnostic usefulness of glutaminase, prostaglandins, and 8-isoprostane as biomarkers of autism spectrum disorders;Role in the Glu-GABA-Gln cycle.BMC neuroscience · 2026Article
- Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Association between decreased taurine levels in the anterior cingulate cortex and restricted and repetitive behaviors in autism spectrum disorder: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Article
- In Vivo Brain GSH: MRS Methods and Clinical Applications.Antioxidants (Basel, Switzerland) · 2021Review
- The Ketogenic Diet Increases In Vivo Glutathione Levels in Patients with Epilepsy.Metabolites · 2020Article
- Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders.Antioxidants & redox signaling · 2019Review
- Comparing the reproducibility of commonly used magnetic resonance spectroscopy techniques to quantify cerebral glutathione.Journal of magnetic resonance imaging : JMRI · 2019Article
- The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.Molecular neurobiology · 2018Review
- Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study.Molecular autism · 2017Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Alice M S Durieux *Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Jamie Horder *Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
M Andreina MendezDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Alice EgertonDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Steven C R WilliamsDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
C Ellie WilsonDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Debbie SpainDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Clodagh MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Dene RobertsonDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Gareth J BarkerDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Declan G MurphyDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
Grainne M McAlonanDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London UK (A.M.S.D., J.H., M.A.M., C.E.W., D.S., C.M., D.G.M., G.M.M.) Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (A.E.) Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (S.W., G.J.B.) Behavioural and Developmental Clinical Academic Group, South London and Maudsley NHS Foundation (D.R.) The Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK (C.M., D.G.M, G.M.M.).
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GB
Funding
Autism Speaks AS8132Department of Health CDRF-2012-03-059Department of Health RP-PG-0606-1045Medical Research Council MR/N026063/1Wellcome TrustWellcome Trust 091300/Z/10/Z
Abstract
Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.
Indexed as
AdolescentAdultAutism Spectrum DisorderBasal GangliaBrain MappingGlutathioneHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPrefrontal CortexProtonsYoung AdultGlutathioneProtonsautismglutathionemagnetic resonance spectroscopyoxidative stressredox
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.