ArticleScientific reports2015
Function does not follow form in gene regulatory circuits.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Basal Xenobot transcriptomics reveals changes and novel control modality in cells freed from organismal influence.Communications biology · 2025Article
- Symmetries in metabolic networks ofPNAS nexus · 2025Article
- Dynamics and bifurcations in genetic circuits with fibration symmetries.Journal of the Royal Society, Interface · 2024Article
- A synthetic synthesis to explore animal evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Kinetic Modeling ofMetabolites · 2022Review
- Differences in evolutionary accessibility determine which equally effective regulatory motif evolves to generate pulses.Genetics · 2021Article
- Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits.ACS synthetic biology · 2021Article
- Dynamical modules in metabolism, cell and developmental biology.Interface focus · 2021Article
- Article
- Emergence of co-expression in gene regulatory networks.PloS one · 2021Article
- Testing biological network motif significance with exponential random graph models.Applied network science · 2021Article
- Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae.Scientific reports · 2020Article
- Circuits with broken fibration symmetries perform core logic computations in biological networks.PLoS computational biology · 2020Article
- Populations of genetic circuits are unable to find the fittest solution in a multilevel genotype-phenotype map.Journal of the Royal Society, Interface · 2020Article
- Article
- Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise.Nature communications · 2019Article
- Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution.Molecular systems biology · 2018Article
- Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant.Nucleic acids research · 2018Article
- Structural properties of genotype-phenotype maps.Journal of the Royal Society, Interface · 2017Review
- A spectrum of modularity in multi-functional gene circuits.Molecular systems biology · 2017Article
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2 authors.
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Abstract
Gene regulatory circuits are to the cell what arithmetic logic units are to the chip: fundamental components of information processing that map an input onto an output. Gene regulatory circuits come in many different forms, distinct structural configurations that determine who regulates whom. Studies that have focused on the gene expression patterns (functions) of circuits with a given structure (form) have examined just a few structures or gene expression patterns. Here, we use a computational model to exhaustively characterize the gene expression patterns of nearly 17 million three-gene circuits in order to systematically explore the relationship between circuit form and function. Three main conclusions emerge. First, function does not follow form. A circuit of any one structure can have between twelve and nearly thirty thousand distinct gene expression patterns. Second, and conversely, form does not follow function. Most gene expression patterns can be realized by more than one circuit structure. And third, multifunctionality severely constrains circuit form. The number of circuit structures able to drive multiple gene expression patterns decreases rapidly with the number of these patterns. These results indicate that it is generally not possible to infer circuit function from circuit form, or vice versa.
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