Evidence map›Paper›PMID 26290058›Full record

ArticleEuropean biophysics journal : EBJ2015

Damped oscillations in a multiple delayed feedback NF-κB signaling module.

Wen-Ting Yu, Jun Tang, Jun Ma, Jin-Ming Luo, Xian-Qing Yang

Abstract read
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In one paragraph

Article in European biophysics journal : EBJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen-Ting YuCollege of science, China University of Mining and Technology, Xuzhou, 221116, China.
Jun TangCollege of science, China University of Mining and Technology, Xuzhou, 221116, China. tjuns1979@126.com.
Jun MaDepartment of Physics, Lanzhou University of Technology, Lanzhou, 730050, China.
Jin-Ming LuoCollege of science, China University of Mining and Technology, Xuzhou, 221116, China.
Xian-Qing YangCollege of science, China University of Mining and Technology, Xuzhou, 221116, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The NF-[Formula: see text]B signaling system regulates a number of cellular processes. Recent studies with simplified models found a damped function of the dual delayed feedback NF-κB signaling module. We use a computational model to investigate how multiple delayed feedback aids achieving damping oscillation in the system and how internal noise can influence the damping function. A curve-fitting method (CFM) is introduced to quantify the damped oscillation. Our results show that (1) the structure of multiple delayed feedback, containing double or triple significantly delayed feedback, determines achieving damped oscillation. (2) Internal noise could aid the system to achieve damped oscillation under almost all circumstances.

Indexed as

Feedback, PhysiologicalModels, TheoreticalPeriodicitySignal TransductionNF-kappa BReaction TimeNF-kappa B

Identifiers

PMID26290058

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.