Evidence map›Paper›PMID 26289942›Full record

ArticleAnnals of biomedical engineering2016

Inkjet-Print Micromagnet Array on Glass Slides for Immunomagnetic Enrichment of Circulating Tumor Cells.

Peng Chen, Yu-Yen Huang, Gauri Bhave, Kazunori Hoshino, Xiaojing Zhang

Registry-linked trialAbstract read
In one paragraph

Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04239105 (Detection and Analysis of Circulating Tumor Cells), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04239105 unknown statusnot on this mapstarted 2020, after this paper: background citation

Detection and Analysis of Circulating Tumor Cells (CTCs) in Patients With Breast Cancer Using a Novel Microfluidic and Raman Spectrum Device

TypeobservationalSponsorXijing HospitalRan2020 to 2022Enrolled120ConditionsBreast Neoplasms, Circulating Tumor CellsArmsMicrofluidic and Raman spectrum
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng ChenDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA.
Yu-Yen HuangThayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.
Gauri BhaveDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA.
Kazunori HoshinoDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Xiaojing ZhangDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, 78712, USA. john.zhang@dartmouth.edu.

Funding

Detection of CarcinomasR01CA139070 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI ZHANG, XIAOJING · 2011 to 2013
$925k
NCI NIH HHS 1R01CA139070NCI NIH HHS R01 CA139070
6 · The paper itself

Abstract

We report an inkjet-printed microscale magnetic structure that can be integrated on regular glass slides for the immunomagnetic screening of rare circulating tumor cells (CTCs). CTCs detach from the primary tumor site, circulate with the bloodstream, and initiate the cancer metastasis process. Therefore, a liquid biopsy in the form of capturing and analyzing CTCs may provide key information for cancer prognosis and diagnosis. Inkjet printing technology provides a non-contact, layer-by-layer and mask-less approach to deposit defined magnetic patterns on an arbitrary substrate. Such thin film patterns, when placed in an external magnetic field, significantly enhance the attractive force in the near-field close to the CTCs to facilitate the separation. We demonstrated the efficacy of the inkjet-print micromagnet array integrated immunomagnetic assay in separating COLO205 (human colorectal cancer cell line) from whole blood samples. The micromagnets increased the capture efficiency by 26% compared with using plain glass slide as the substrate.

Indexed as

Neoplastic Cells, CirculatingCell Line, TumorGlassHumansImmunomagnetic SeparationMicroarray AnalysisCirculating tumor cellsImmunomagnetic cell separationInkjet printingMicrofluidicMicromagnets

Identifiers

PMID26289942
PMCPMC4761332

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.