ArticleScientific reports2015
Reconsolidation of a cocaine associated memory requires DNA methyltransferase activity in the basolateral amygdala.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- The ventral hippocampus and nucleus accumbens as neural substrates for cocaine contextual memory reconsolidation.Translational psychiatry · 2025Article
- Drug memory reconsolidation: from molecular mechanisms to the clinical context.Translational psychiatry · 2023Review
- Article
- DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory.Frontiers in molecular neuroscience · 2022Article
- Epigenetic Mechanisms in Drug Relapse.Biological psychiatry · 2021Review
- The Mechanisms and Boundary Conditions of Drug Memory Reconsolidation.Frontiers in neuroscience · 2021Review
- Disrupting Reconsolidation by Systemic Inhibition of mTOR Kinase via Rapamycin Reduces Cocaine-Seeking Behavior.Frontiers in pharmacology · 2021Article
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- Iron Oxide Nanoparticles Affects Behaviour and Monoamine Levels in Mice.Neurochemical research · 2019Article
- Regulation of Garcinol on Histone Acetylation in the Amygdala and on the Reconsolidation of a Cocaine-Associated Memory.Frontiers in behavioral neuroscience · 2019Article
- Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference.CNS neuroscience & therapeutics · 2018Article
- Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- The Naturally Occurring Compound Garcinia Indica Selectively Impairs the Reconsolidation of a Cocaine-Associated Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation.Epigenetics · 2016Article
- The Use of DREADDs to Deconstruct Behavior.Frontiers in genetics · 2016Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug addiction is considered an aberrant form of learning, and drug-associated memories evoked by the presence of associated stimuli (drug context or drug-related cues) contribute to recurrent craving and reinstatement. Epigenetic changes mediated by DNA methyltransferase (DNMT) have been implicated in the reconsolidation of fear memory. Here, we investigated the role of DNMT activity in the reconsolidation of cocaine-associated memories. Rats were trained over 10 days to intravenously self-administer cocaine by nosepokes. Each injection was paired with a light/tone conditioned stimulus (CS). After acquisition of stable self-administration behaviour, rats underwent nosepoke extinction (10 d) followed by cue-induced reactivation and subsequent cue-induced and cocaine-priming + cue-induced reinstatement tests or subsequently tested to assess the strength of the cocaine-associated cue as a conditioned reinforcer to drive cocaine seeking behaviour. Bilateral intra-basolateral amygdala (BLA) infusion of the DNMT inhibitor5-azacytidine (5-AZA, 1 μg per side) immediately following reactivation decreased subsequent reinstatement induced by cues or cocaine priming as well as cue-maintained cocaine-seeking behaviour. In contrast, delayed intra-BLA infusion of 5-AZA 6 h after reactivation or 5-AZA infusion without reactivation had no effect on subsequent cue-induced reinstatement. These findings indicate that memory reconsolidation for a cocaine-paired stimulus depends critically on DNMT activity in the BLA.
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