ArticleJournal of molecular evolution2015
Beyond the Frozen Accident: Glycine Assignment in the Genetic Code.
Article in Journal of molecular evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- On the Evolutionary History of the Twenty Encoded Amino Acids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides.Life (Basel, Switzerland) · 2019Article
- Phenotypic Graphs and Evolution Unfold the Standard Genetic Code as the Optimal.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator.Molecular biology and evolution · 2018Article
- Binding Properties of Split tRNA to the C-terminal Domain of Methionyl-tRNA Synthetase of Nanoarchaeum equitans.Journal of molecular evolution · 2017Article
- On the Uniqueness of the Standard Genetic Code.Life (Basel, Switzerland) · 2017Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Origins and Early Evolution of the tRNA Molecule.Life (Basel, Switzerland) · 2015Review
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
tRNA with a terminal UCCA-3' forms a structure in which the 3'-sequence folds back. The adenine of glycyl-AMP can base-pair with the uridine of the UCCA-3' region, which places the glycine residue in close proximity to the 3'-terminal adenosine of tRNA, possibly enabling the transfer of glycine from glycyl-AMP to tRNA. Thus, the UCCA-3'-containing tRNA (as seen in eubacterial tRNA(Gly)s) would possess an intrinsic property of glycylation by glycyl-AMP. This model provides a new perspective on the origins of the glycine assignment in the genetic code, beyond the "frozen accident" hypothesis.
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