ArticleScientific reports2015
Discerning the differential molecular pathology of proliferative middle ear lesions using Raman spectroscopy.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
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- Association between Single Nucleotide Polymorphisms ofFoods (Basel, Switzerland) · 2024Article
- Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024Review
- Optical Identification of Middle Ear Infection.Molecules (Basel, Switzerland) · 2020Review
- Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy.Journal of biomedical optics · 2019Article
- Quality Analysis of Minerals Formed by Jaw Periosteal Cells under Different Culture Conditions.International journal of molecular sciences · 2019Article
- Label-free spectrochemical probe for determination of hemoglobin glycation in clinical blood samples.Journal of biophotonics · 2018Article
- Differential diagnosis of otitis media with effusion using label-free Raman spectroscopy: A pilot study.Journal of biophotonics · 2018Article
- Label-free Raman hyperspectral imaging analysis localizes the cyanogenic glucoside dhurrin to the cytoplasm in sorghum cells.Scientific reports · 2018Article
- Low-Coherence Interferometric Fiber-Optic Sensors with Potential Applications as Biosensors.Sensors (Basel, Switzerland) · 2017Article
- Label-Free Raman Spectroscopy Detects Stromal Adaptations in Premetastatic Lungs Primed by Breast Cancer.Cancer research · 2017Article
- Different Phases of Breast Cancer Cells: Raman Study of Immortalized, Transformed, and Invasive Cells.Biosensors · 2016Article
- Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy.Journal of otology · 2016Article
- A label-free approach by infrared spectroscopic imaging for interrogating the biochemistry of diabetic nephropathy progression.Kidney international · 2016Article
- Piriformospora indica: Potential and Significance in Plant Stress Tolerance.Frontiers in microbiology · 2016Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Despite its widespread prevalence, middle ear pathology, especially the development of proliferative lesions, remains largely unexplored and poorly understood. Diagnostic evaluation is still predicated upon a high index of clinical suspicion on otoscopic examination of gross morphologic features. We report the first technique that has the potential to non-invasively identify two key lesions, namely cholesteatoma and myringosclerosis, by providing real-time information of differentially expressed molecules. In addition to revealing signatures consistent with the known pathobiology of these lesions, our observations provide the first evidence of the presence of carbonate- and silicate-substitutions in the calcium phosphate plaques found in myringosclerosis. Collectively, these results demonstrate the potential of Raman spectroscopy to not only provide new understanding of the etiology of these conditions by defining objective molecular markers but also aid in margin assessment to improve surgical outcome.
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