ArticleJournal of veterinary internal medicine
Serum Surfactant Protein D and Haptoglobin as Potential Biomarkers for Inflammatory Airway Disease in Horses.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Biomarkers of equine asthma: A review of the current literature.Veterinary research communications · 2026Review
- Regulatory mechanisms of haptoglobin on particulate matter-induced epithelial-to-mesenchymal transition in bronchial epithelial cells.Journal of thoracic disease · 2024Article
- Equine Asthma Diagnostics: Review of Influencing Factors and Difficulties in Diagnosing Subclinical Disease.Animals : an open access journal from MDPI · 2024Review
- Serum Vitamin D Level Is Unchanged in Equine Asthma.Animals : an open access journal from MDPI · 2024Article
- Diagnostic utility of acute phase proteins and their ability to guide antibiotic usage in pigs, horses, and cattle: a mapping review.Acta veterinaria Scandinavica · 2024Review
- Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity.Frontiers in immunology · 2022Article
- Exercise-induced airflow changes in horses with asthma measured by electrical impedance tomography.Journal of veterinary internal medicine · 2021Article
- Research article expression of surfactant protein-A and D, and CD9 in lungs of 1 and 30 day old foals.BMC veterinary research · 2021Article
- Light and electron-microscopic localization of CD9 and surfactant protein A and D in normal lungs of the horse.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.The Veterinary clinics of North America. Equine practice · 2020Review
- Equine Asthma: Current Understanding and Future Directions.Frontiers in veterinary science · 2020Review
- Investigation of blood biomarkers for the diagnosis of mild to moderate asthma in horses.Journal of veterinary internal medicine · 2019Article
- Serum amyloid A in equine health and disease.Equine veterinary journal · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe identification of serum biomarkers of lung inflammation would facilitate the diagnosis of inflammatory airway disease (IAD) in horses. HYPOTHESIS: Horses with IAD have higher serum concentrations of markers of inflammation compared to controls. ANIMALS: Twelve horses with IAD and 10 control horses.
methodsThis was a prospective case-control study. Blood and BALF were collected from horses with IAD and controls. Serum concentration of surfactant protein D (SP-D), haptoglobin, serum amyloid A (SAA) and of the soluble form of triggering receptor expressed on myeloid cells 1 (sTREM-1) was measured using commercial ELISA tests.
resultsHorses with IAD had higher serum concentration (log-transformed values) of SP-D (mean ± SD: 1.773 ± 0.51), haptoglobin (6.657 ± 0.202) and SAA (0.128 ± 0.396) compared to controls (0.942 ± 0.226, 6.38 ± 0.22, -0.398 ± 0.319, respectively; P < .01 for all). Furthermore, the concentrations of SP-D and haptoglobin combined allowed differentiating the 2 groups (IAD: 8.43 ± 0.564, controls: 7.322 ± 0.249, P < .0001) with a sensitivity and specificity of 100% when a cut-off of 7.70 (log value) was employed. CONCLUSIONS AND CLINICAL IMPORTANCE: Surfactant protein D and haptoglobin serum concentrations could be a diagnostic aid in IAD. Further studies are necessary to establish the specificity of our findings before they can be applied in everyday practice.
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Registered trials
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