ArticleJournal of neurophysiology2015
Open-loop organization of thalamic reticular nucleus and dorsal thalamus: a computational model.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model.PLoS computational biology · 2026Article
- Biophysical modeling of thalamocortical circuit dynamics: species-specific insights into neural synchrony, sleep spindles, and circuit mechanisms.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Closed-Loop Connectivity Best Supports Angular Tuning and Sleep Dynamics in a Biophysical Thalamocortical Circuit Model.bioRxiv : the preprint server for biology · 2025Article
- Article
- Local activation of CB1 receptors by synthetic and endogenous cannabinoids dampens burst firing mode of reticular thalamic nucleus neurons in rats under ketamine anesthesia.Experimental brain research · 2024Article
- Review
- Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.bioRxiv : the preprint server for biology · 2024Article
- Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits.Network neuroscience (Cambridge, Mass.) · 2023Article
- Remembrance of things perceived: Adding thalamocortical function to artificial neural networks.Frontiers in integrative neuroscience · 2023Review
- Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons.Development (Cambridge, England) · 2022Article
- Hitting The Right Spot: NMDA Receptors in the Auditory Thalamus May Hold the Key to Understanding Schizophrenia.The international journal of neuropsychopharmacology · 2020Article
- Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation.Neural plasticity · 2020Article
- Projection from the Amygdala to the Thalamic Reticular Nucleus Amplifies Cortical Sound Responses.Cell reports · 2019Article
- Cortical Responses to Input From Distant Areas are Modulated by Local Spontaneous Alpha/Beta Oscillations.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A novel mutual information estimator to measure spike train correlations in a model thalamocortical network.Journal of neurophysiology · 2018Article
- Visual Attention Deficits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex.Computational psychiatry (Cambridge, Mass.) · 2018Article
- Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals.Frontiers in neurology · 2018Article
- Auditory thalamic circuits and GABAHearing research · 2017Review
- A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway.Brain sciences · 2017Review
- Thalamic state control of cortical paired-pulse dynamics.Journal of neurophysiology · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
The thalamic reticular nucleus (TRN) is a shell of GABAergic neurons that surrounds the dorsal thalamus. Previous work has shown that TRN neurons send GABAergic projections to thalamocortical (TC) cells to form reciprocal, closed-loop circuits. This has led to the hypothesis that the TRN is responsible for oscillatory phenomena, such as sleep spindles and absence seizures. However, there is emerging evidence that open-loop circuits are also found between TRN and TC cells. The implications of open-loop configurations are not yet known, particularly when they include time-dependent nonlinearities in TC cells such as low-threshold bursting. We hypothesized that low-threshold bursting in an open-loop circuit could be a mechanism by which the TRN could paradoxically enhance TC activation, and that enhancement would depend on the relative timing of TRN vs. TC cell stimulation. To test this, we modeled small circuits containing TC neurons, TRN neurons, and layer 4 thalamorecipient cells in both open- and closed-loop configurations. We found that open-loop TRN stimulation, rather than universally depressing TC activation, increased cortical output across a broad parameter space, modified the filter properties of TC neurons, and altered the mutual information between input and output in a frequency-dependent and T-type calcium channel-dependent manner. Therefore, an open-loop model of TRN-TC interactions, rather than suppressing transmission through the thalamus, creates a tunable filter whose properties may be modified by outside influences onto the TRN. These simulations make experimentally testable predictions about the potential role for the TRN for flexible enhancement of cortical activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.