ArticleThe American journal of clinical nutrition2015
Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study.
Article in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study.Paediatric and perinatal epidemiology · 2021Trial
- Less than what? Response to alcohol consumption recommendations in the 2025-2030 dietary guidelines for Americans.Lancet regional health. Americas · 2026Review
- Associations between physical activity, sleep patterns and diet quality and menstrual health symptoms in midlife: evidence from the 1970 British Cohort Study.BMC women's health · 2026Article
- Characteristics of Menstrual Cycles, Prevalence of Menstrual Disorders in Young Women and Their Relationship to Hormonal Contraceptive Use.Health science reports · 2026Article
- Binge alcohol and the neuroendocrinology of the aging female.Frontiers in neuroendocrinology · 2025Review
- Prevalence and Risk Factors of Menstrual Disorders in Korean Women.Healthcare (Basel, Switzerland) · 2025Article
- Estrogen and alcohol use in women: a targeted literature review.Archives of women's mental health · 2025Review
- Investigation of Uncovering Molecular Mechanisms of Alcohol-Induced Female Infertility-A Rational Approach.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Associations of sex-related steroid hormones and proteins with alcohol dependence: A United Kingdom Biobank study.Drug and alcohol dependence · 2023Article
- Alcohol use and motives for drinking across the menstrual cycle in a psychiatric outpatient sample.Alcohol, clinical & experimental research · 2023Article
- Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice.Addiction neuroscience · 2022Article
- Review
- Sex, Gender, and Alcohol Use: Implications for Women and Low-Risk Drinking Guidelines.International journal of environmental research and public health · 2022Review
- Can Nutrition Help in the Treatment of Infertility?Preventive nutrition and food science · 2021Review
- Magnitude and associated factors of menstrual irregularity among undergraduate students of Debre Berhan University, Ethiopia.Reproductive health · 2021Article
- Effects of Environment and Lifestyle Factors on Premature Ovarian Failure.Advances in experimental medicine and biology · 2021Article
- Heavy menstrual bleeding among women aged 18-50 years living in Beijing, China: prevalence, risk factors, and impact on daily life.BMC women's health · 2019Article
- Modifiable life style factors and risk for incident endometriosis.Paediatric and perinatal epidemiology · 2019Article
- High-fat-diet impaired mitochondrial function of cumulus cells but improved the efficiency of parthenogenetic embryonic quality in mice.Animal cells and systems · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlthough habitual low-to-moderate alcohol intake has been linked with reduced all-cause mortality and morbidity, the effect of recent alcohol intake on female reproductive function has not been clearly established.
objectiveWe assessed the relation between acute alcohol consumption, reproductive hormones, and markers of menstrual cycle dysfunction including sporadic anovulation, irregular cycle length, luteal phase deficiency, long menses, and heavy blood loss.
designA total of 259 healthy, premenopausal women from Western New York were followed for ≤2 menstrual cycles (2005-2007) and provided fasting blood specimens during ≤8 visits/cycle and four 24-h dietary recalls/cycle. Linear mixed models were used to estimate associations between previous day's alcohol intake and hormone concentrations, whereas Poisson regression was used to assess RR of cycle-average alcohol intake and menstrual cycle function.
resultsFor every alcoholic drink consumed, the geometric mean total and free estradiol, total and free testosterone, and luteinizing hormone were higher by 5.26% (95% CI: 1.27%, 9.41%), 5.82% (95% CI: 1.81%, 9.99%), 1.56% (95% CI: 0.23%, 2.90%), 1.42% (95% CI: 0.02%, 2.84%), and 6.18% (95% CI: 2.02%, 10.52%), respectively, after adjustment for age, race, percentage of body fat, perceived stress, pain-medication use, sexual activity, caffeine, and sleep. Binge compared with nonbinge drinking (defined as reporting ≥4 compared with <4 drinks/d, respectively) was associated with 64.35% (95% CI: 18.09%, 128.71%) and 63.53% (95% CI: 17.41%, 127.73%) higher total and free estradiol. No statistically significant associations were shown between cycle-average alcohol intake and menstrual cycle function.
conclusionAlthough recent moderate alcohol intake does not appear to have adverse short-term effects on menstrual cycle function, including sporadic anovulation, potential protective and deleterious long-term effects of alterations in reproductive hormones on other chronic diseases warrant additional investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.