ArticleEnvironmental science and pollution research international2015
Cadmium exposure and the risk of breast cancer in Chaoshan population of southeast China.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- The preventive and carcinogenic effect of metals on cancer: a systematic review.BMC public health · 2024Pooled it
- Association Between Cd Exposure and Risk of Prostate Cancer: A PRISMA-Compliant Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- 5'-Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation-Mediated PAK2 Upregulation to Promote Cadmium-Induced Breast Cancer Progression by Impairing Autophagic Flux.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- DNA damage response inhibition is an early event in cadmium-induced breast carcinogenesis.Toxicology and applied pharmacology · 2025Article
- Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics.Cancer causes & control : CCC · 2024Article
- Cadmium Toxicity and Health Effects-A Brief Summary.Molecules (Basel, Switzerland) · 2023Review
- Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression.Environmental science and pollution research international · 2022Article
- Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study.Scientific reports · 2021Article
- Breast cancer and occupational exposures: an integrative review of the literature.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT · 2021Review
- High Prevalence of Triple-Negative Breast Cancer in Southern Shaanxi Province, China.Cancer management and research · 2021Article
- Breast cancer in the Baixada Santista region and its relationship to contaminated areas.Environmental science and pollution research international · 2020Article
- The Effects of Cadmium Toxicity.International journal of environmental research and public health · 2020Review
- The Protective Impact of Black Chokeberry Fruit Extract (Oxidative medicine and cellular longevity · 2019Article
- Connecting gastrointestinal cancer risk to cadmium and lead exposure in the Chaoshan population of Southeast China.Environmental science and pollution research international · 2018Article
- Melatonin: A Molecule for Reducing Breast Cancer Risk.Molecules (Basel, Switzerland) · 2018Review
- Blood cadmium levels associated with short distant metastasis-free survival time in invasive breast cancer.Environmental science and pollution research international · 2017Article
- State of the evidence 2017: an update on the connection between breast cancer and the environment.Environmental health : a global access science source · 2017Review
- Heavy Metal Accumulation is Associated with Molecular and Pathological Perturbations in Liver of Variola louti from the Jeddah Coast of Red Sea.International journal of environmental research and public health · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, there is increasing evidence indicating a link between cadmium exposure and human breast cancer. This study was aimed to explore the relationship between blood cadmium burden and the risk of breast cancer in Chaoshan women with no occupational exposure. Blood cadmium levels (BCLs) were determined in whole blood of 186 breast cancer cases and 139 controls. Basic clinical data and information of age, occupation, blood types, family cancer history, and disease history, as well as other demographic characteristics were collected from medical records. BCLs were detected by graphite-furnace atomizer absorption spectrophotometer (GFAAS). BCLs and proportions of BCLs over 3 μg/L between cases and controls were compared. The relationships between BCLs and breast cancer were explored by comparing BCL differences between/among different characteristics of investigated factors. In addition, BCLs within cases were also compared in relation to the disease clinical stages, tumor-node-metastasis (TNM) stages, and estrogen receptor (ER), progesterone receptor (PR), and Cerb-B2 expressions. The breast cancer patients had a higher median concentration of blood cadmium (2.28, interquartile range 1.57-3.15 μg/L) than the controls (1.77, 1.34-2.57 μg/L; P = 0.001). The proportion of BCLs over 3 μg/L was 2.35 times higher in the breast cancer cases than that of the controls after adjusting for age. Cadmium tends to accumulate in the human body with age and body mass index (BMI) but not associates with type of job, family history, disease history, and other investigated characters. With the increase of clinical stages and T and M stages, the BCLs in the breast cancer cases also increased. BCLs were positively associated with Cerb-B2 expression (r = 0.152, P = 0.038) but not significantly associated with ER and PR expressions. The data obtained show that cadmium concentration is significantly higher in blood of breast cancer patients in comparison to healthy controls. Cadmium seems to be a risk factor of breast cancer, and high cadmium exposure was observed in advanced stages of this disease, which indicates that it may promote the development of breast cancer.
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