ReviewCurrent cardiology reports2015
The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms.
Review in Current cardiology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07244809 (Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity), which is not on this map. Cited by 129 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Who cites it
129 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Is parental unemployment associated with increased risk of adverse childhood experiences? A systematic review and meta-analysis.Journal of public health (Oxford, England) · 2023Pooled it
- The Role of Social Determinants of Health in Cardiovascular Diseases: An Umbrella Review.Journal of the American Heart Association · 2023Pooled it
- The association between adverse childhood experiences and childhood obesity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis.The Lancet. Public health · 2019Pooled it
- Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Physical activity, diet and other behavioural interventions for improving cognition and school achievement in children and adolescents with obesity or overweight.The Cochrane database of systematic reviews · 2018Pooled it
- Mindfulness for heart and mind: Mindfulness-based blood pressure reduction randomized clinical trial for depression symptoms.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Trial
- Childhood Adversities and the ATTACHInternational journal of environmental research and public health · 2024Trial
- Early Life Trauma Is Associated With Increased Microvolt T-Wave Alternans During Mental Stress Challenge: A Substudy of Mental Stress Ischemia: Prognosis and Genetic Influences.Journal of the American Heart Association · 2022Trial
- Early life stress blunts time-of-day-specific autonomic function in adult male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Association between adverse childhood experiences and accelerated aging of middle-aged and older Chinese: based on the China health and retirement longitudinal study.BMC public health · 2026Observational
- Social determinants of health across the lifecourse and chronic disease risk: available data and seminal findings from the Atherosclerosis Risk in Communities (ARIC) Study.American journal of epidemiology · 2026Review
- Adverse childhood experiences and well-being in middle-aged men in South Korea: mediating role of andropause symptoms.Health and quality of life outcomes · 2026Article
- Parental violent discipline and adolescent health: is there a different effect when one or both parents are involved?European journal of public health · 2026Article
- Associations of childhood exposure to interparental physical violence and verbal conflict with the risk of adult-onset diabetes.Journal of global health · 2026Article
- Associations Between Adverse Childhood Experiences and Physical Activity, Recreational Screen Time, and Sleep Among U.S. Children.Behavioral sciences (Basel, Switzerland) · 2026Article
- Adverse childhood experiences and hypertension jointly increase cardiovascular risk: evidence from three national aging cohorts.BMC public health · 2026Article
- Childhood adversity and increased cytokine release from peripheral mononuclear cells of CHD patients - a pilot study.BMC cardiovascular disorders · 2026Article
- Childhood Maltreatment and Cardiovascular Health: Role of Sex and Life's Essential 8 in the U.K. Biobank.JACC. Advances · 2026Article
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.