Evidence map›Paper›PMID 26289217›Full record

ReviewFuture oncology (London, England)2015

Next-generation prognostic assessment for diffuse large B-cell lymphoma.

Ashley D Staton, Jean L Koff, Qiushi Chen, Turgay Ayer, Christopher R Flowers

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. CAR T-cell Therapy for Diffuse Large B-cell Lymphoma in Canada: A Cost-Utility Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2024
    Article
  2. Review
  3. Large-scale North American cancer survivorship surveys: 2011-2019 update.Journal of cancer survivorship : research and practice · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashley D StatonDepartment of Hematology & Medical Oncology, Emory University, Atlanta, GA 30322, USA.
Jean L KoffDepartment of Hematology & Medical Oncology, Emory University, Atlanta, GA 30322, USA.
Qiushi ChenH Milton Stewart School of Industrial & Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA.
Turgay AyerH Milton Stewart School of Industrial & Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA.
Christopher R FlowersDepartment of Hematology & Medical Oncology, Emory University, Atlanta, GA 30322, USA.

Funding

The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study (Supplement)U01CA195568 · NCI · MAYO CLINIC ROCHESTER · PI CERHAN, JAMES R, FLOWERS, CHRISTOPHER R · 2015 to 2025
$22.1M
Biological Variants Underlying Racial Differences in LymphomaR21CA158686 · NCI · EMORY UNIVERSITY · PI FLOWERS, CHRISTOPHER R · 2012 to 2013
$371k
NCI NIH HHS R21 CA158686NCI NIH HHS U01 CA195568
6 · The paper itself

Abstract

Current standard of care therapy for diffuse large B-cell lymphoma (DLBCL) cures a majority of patients with additional benefit in salvage therapy and autologous stem cell transplant for patients who relapse. The next generation of prognostic models for DLBCL aims to more accurately stratify patients for novel therapies and risk-adapted treatment strategies. This review discusses the significance of host genetic and tumor genomic alterations seen in DLBCL, clinical and epidemiologic factors, and how each can be integrated into risk stratification algorithms. In the future, treatment prediction and prognostic model development and subsequent validation will require data from a large number of DLBCL patients to establish sufficient statistical power to correctly predict outcome. Novel modeling approaches can augment these efforts.

Indexed as

Epidemiologic FactorsGenetic Predisposition to DiseaseGenomicsHumansLymphoma, Large B-Cell, DiffuseModels, TheoreticalPopulation SurveillancePrognosisReproducibility of ResultsStandard of CareTreatment Outcomeactivated B cellsCox regression modelsdiffuse large B-cell lymphomagene-expression profilinglogistic regressionmolecular subtypingrisk prediction models

Identifiers

PMID26289217
PMCPMC4644669

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.