Evidence map›Paper›PMID 26289159›Full record

ArticleEuropean journal of immunology2015

Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection.

Matthew B Buechler, Griffin M Gessay, Shivani Srivastava, Daniel J Campbell, Jessica A Hamerman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review ofFrontiers in microbiology · 2018
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Matthew B BuechlerDepartment of Immunology, University of Washington, Seattle, WA, USA.
Griffin M GessayImmunology Research Program, Benaroya Research Institute (BRI) at Virginia Mason, Seattle, WA, USA.
Shivani SrivastavaDepartment of Immunology, University of Washington, Seattle, WA, USA.
Daniel J CampbellDepartment of Immunology, University of Washington, Seattle, WA, USA.
Jessica A HamermanDepartment of Immunology, University of Washington, Seattle, WA, USA.
Benaroya Research InstituteUniversity of Washington · USVirginia Mason Medical Center · US

Funding

Thymic Stromal Lymphopoietin (TSLP) and Lung Inflammation and ImmP01HL098067 · NHLBI · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI FREVERT, CHARLES WAYNE · 2010 to 2014
$13.5M
Homing and Homeostasis of Regulatory T cellsR01AI067750 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2006 to 2010
$2.6M
Regulation of dendritic cell inflammatory responsesR01AI081948 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HAMERMAN, JESSICA A · 2010 to 2014
$2.2M
Functional specialization of Foxp3+ regulatory T cellsR01AI085130 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2010 to 2014
$2.1M
Regulation of TSLP-Mediated Skin InflammationR01AR055695 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J, HAMERMAN, JESSICA A · 2009 to 2013
$2.0M
BCAP/PI3K regulation of innate immunity to Listeria monocytogenesR01AI113325 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI HAMERMAN, JESSICA A · 2015 to 2019
$2.0M
Homing and Homeostasis of Regulatory T cellsR56AI067750 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2012 to 2012
$427k
NHLBI NIH HHS HL098067NHLBI NIH HHS P01 HL098067NIAID NIH HHS AI067750NIAID NIH HHS AI085130NIAID NIH HHS AI113325NIAID NIH HHS R01 AI067750NIAID NIH HHS R01 AI081948NIAID NIH HHS R01 AI085130NIAID NIH HHS R01 AI113325NIAID NIH HHS R56 AI067750NIAMS NIH HHS AR055695NIAMS NIH HHS R01 AR055695
6 · The paper itself

Abstract

Release of inflammatory monocytes from the bone marrow (BM) into the blood is an important physiological response to infection, but the mechanisms regulating this phenomenon during viral infection are not completely defined. Here, we show that low-dose infection with lymphocytic choriomeningitis virus (LCMV) caused rapid, transient inflammatory monocytosis that required type I interferon (IFN) and Toll-like receptor (TLR) 7 signaling. Type I IFN and TLR7 signals were critical for induction of IFN-stimulated gene expression and CCR2 ligand upregulation in the BM microenvironment in response to LCMV infection. Experiments utilizing BM chimeric mice demonstrated that type I IFN and TLR7 signaling on either hematopoietic or nonhematopoietic cells was sufficient to initiate monocytosis in response to LCMV infection. BM plasmacytoid dendritic cells (pDCs) generated type I IFN directly ex vivo, suggesting that pDCs are a hematopoietic contributor of type I IFN in the BM early during LCMV infection. Overall, we describe novel roles for type I IFN and TLR7 signaling in nonhematopoietic cells and BM pDCs in directing IFN-stimulated gene and CCR2 ligand expression in the BM to initiate an increase in blood inflammatory monocytes during viral infection.

Indexed as

Lymphocytic choriomeningitis virusAnimalsArenaviridae InfectionsCell SeparationEnzyme-Linked Immunosorbent AssayFlow CytometryInterferon Type IMembrane GlycoproteinsMiceMice, Inbred C57BLMonocytesReal-Time Polymerase Chain ReactionSignal TransductionToll-Like Receptor 7Interferon Type IMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7Lymphocytic choriomeningitis virus infectionMonocytesPlasmacytoid DCTLR7Type I IFN

Identifiers

PMID26289159
PMCPMC4675142
OpenAlexW2132554557

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.