Trial reportPsychiatry and clinical neurosciences2016
Frontolimbic neural circuit changes in emotional processing and inhibitory control associated with clinical improvement following transference-focused psychotherapy in borderline personality disorder.
Trial report in Psychiatry and clinical neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychotherapy and inhibitory control: Insights from fMRI research.Psychiatry and clinical neurosciences · 2026Pooled it
- Psychotherapy for Borderline Personality Disorder: Progress and Remaining Challenges.Current psychiatry reports · 2017Pooled it
- Altered asymmetries of the structural networks comprising the fronto-limbic brain circuitry of preterm infants.Scientific reports · 2021Trial
- Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment.Human brain mapping · 2026Article
- Neural predictors of psychotherapy response in borderline personality disorder: a mini review of neuroimaging studies.Frontiers in human neuroscience · 2026Review
- Transference interpretation and psychotherapy outcome: a systematic review of a no-consensus relationship.Research in psychotherapy (Milano) · 2024Article
- The First "Hit" to the Endocannabinoid System? Associations Between Prenatal Cannabis Exposure and Frontolimbic White Matter Pathways in Children.Biological psychiatry global open science · 2024Article
- Article
- Alternation in functional connectivity within default mode network after psychodynamic psychotherapy in borderline personality disorder.Annals of general psychiatry · 2023Article
- Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022Review
- Amygdala response predicts clinical symptom reduction in patients with borderline personality disorder: A pilot fMRI study.Frontiers in behavioral neuroscience · 2022Article
- Differential neural response to psychoanalytic intervention techniques during structural interviewing: A single-case analysis using EEG.Frontiers in human neuroscience · 2022Article
- Sparse Hierarchical Representation Learning on Functional Brain Networks for Prediction of Autism Severity Levels.Frontiers in neuroscience · 2022Article
- Hypersexuality and Impulsivity in Self-Referred Men With Sexual Interest in Minors: Are They Related? Do They Change During Treatment? An Exploratory Pilot Study.Sexual medicine · 2021Article
- Three Dimensional Approaches to Personality Disorders: a Review on Personality Functioning, Personality Structure, and Personality Organization.Current psychiatry reports · 2021Review
- Use of random matrix theory in the discovery of resting state brain networks.Magnetic resonance imaging · 2021Article
- It's Not That Great Anymore: The Central Role of Defense Mechanisms in Grandiose and Vulnerable Narcissism.Frontiers in psychiatry · 2021Article
- Neural Changes in Borderline Personality Disorder After Dialectical Behavior Therapy-A Review.Frontiers in psychiatry · 2021Review
- Insomnia in Patients with Borderline Personality Disorder.Nature and science of sleep · 2021Review
- Neuroscience of Object Relations in Health and Disorder: A Proposal for an Integrative Model.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
aimsBorderline personality disorder (BPD) is characterized by self-regulation deficits, including impulsivity and affective lability. Transference-focused psychotherapy (TFP) is an evidence-based treatment proven to reduce symptoms across multiple cognitive-emotional domains in BPD. This pilot study aimed to investigate neural activation associated with, and predictive of, clinical improvement in emotional and behavioral regulation in BPD following TFP.
methodsBPD subjects (n = 10) were scanned pre- and post-TFP treatment using a within-subjects design. A disorder-specific emotional-linguistic go/no-go functional magnetic resonance imaging paradigm was used to probe the interaction between negative emotional processing and inhibitory control.
resultsAnalyses demonstrated significant treatment-related effects with relative increased dorsal prefrontal (dorsal anterior cingulate, dorsolateral prefrontal, and frontopolar cortices) activation, and relative decreased ventrolateral prefrontal cortex and hippocampal activation following treatment. Clinical improvement in constraint correlated positively with relative increased left dorsal anterior cingulate cortex activation. Clinical improvement in affective lability correlated positively with left posterior-medial orbitofrontal cortex/ventral striatum activation, and negatively with right amygdala/parahippocampal activation. Post-treatment improvements in constraint were predicted by pre-treatment right dorsal anterior cingulate cortex hypoactivation, and pre-treatment left posterior-medial orbitofrontal cortex/ventral striatum hypoactivation predicted improvements in affective lability.
conclusionsThese preliminary findings demonstrate potential TFP-associated alterations in frontolimbic circuitry and begin to identify neural mechanisms associated with a psychodynamically oriented psychotherapy.
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