ArticleNeuroImage. Clinical2015
Altered whole-brain white matter networks in preclinical Alzheimer's disease.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 101 citations in OpenAlex.
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- Retinal layer assessments as potential biomarkers for brain atrophy in the Rhineland Study.Scientific reports · 2022Trial
- Early-life cognitive intervention preserves brain function in aged TgF344-AD rats with sex-specific effects.iScience · 2026Article
- Local brain connectome parameters across the spectrum of clinical cognitive decline.Frontiers in neuroscience · 2026Article
- Sex differences in diffusion-weighted imaging outcomes in autosomal dominant Alzheimer's disease.Brain communications · 2026Article
- Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- The brain network hub degeneration in Alzheimer's disease.Biophysics reports · 2024Article
- Article
- Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities.FEBS open bio · 2024Review
- Temporal Alterations in White Matter in AneNeuro · 2024Article
- Structural Network Topology Reveals Higher Brain Resilience in Individuals with Preclinical Alzheimer's Disease.Brain connectivity · 2023Article
- Diffusion tensor imaging tractography in the one-humped camel (Frontiers in veterinary science · 2023Article
- Sleep deprivation aggravated amyloid β oligomers-induced damage to the cerebellum of rats: Evidence from magnetic resonance imaging.Aging brain · 2023Article
- Sex differences in the structural rich-club connectivity in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer's disease (AD) neuropathology: A hypothesis and review.Frontiers in aging neuroscience · 2023Article
- Sex moderates the association between age and myelin water fraction in the cingulum and fornix among older adults without dementia.Frontiers in aging neuroscience · 2023Article
- Evaluation of functional MRI-based human brain parcellation: a review.Journal of neurophysiology · 2022Review
- White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer's disease that emerge prior to dementia.Alzheimer's research & therapy · 2022Article
- Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.Alzheimer's & dementia (New York, N. Y.) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Surrogates of whole-brain white matter (WM) networks reconstructed using diffusion tensor imaging (DTI) are novel markers of structural brain connectivity. Global connectivity of networks has been found impaired in clinical Alzheimer's disease (AD) compared to cognitively healthy aging. We hypothesized that network alterations are detectable already in preclinical AD and investigated major global WM network properties. Other structural markers of neurodegeneration typically affected in prodromal AD but seeming largely unimpaired in preclinical AD were also examined. 12 cognitively healthy elderly with preclinical AD as classified by florbetapir-PET (mean age 73.4 ± 4.9) and 31 age-matched controls without cerebral amyloidosis (mean age 73.1 ± 6.7) from the ADNI were included. WM networks were reconstructed from DTI using tractography and graph theory. Indices of network capacity and the established imaging markers of neurodegeneration hippocampal volume, and cerebral glucose utilization as measured by fludeoxyglucose-PET were compared between the two groups. Additionally, we measured surrogates of global WM integrity (fractional anisotropy, mean diffusivity, volume). We found an increase of shortest path length and a decrease of global efficiency in preclinical AD. These results remained largely unchanged when controlling for WM integrity. In contrast, neither markers of neurodegeneration nor WM integrity were altered in preclinical AD subjects. Our results suggest an impairment of WM networks in preclinical AD that is detectable while other structural imaging markers do not yet indicate incipient neurodegeneration. Moreover, these findings are specific to WM networks and cannot be explained by other surrogates of global WM integrity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.