ReviewThe Neurohospitalist2015
What to do With Wake-Up Stroke.
Review in The Neurohospitalist, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Wake-up stroke and sleep-disordered breathing: a meta-analysis of current studies.Journal of neurology · 2018Pooled it
- Rise and restore: the role of cerebral angiogram with mechanical thrombectomy in the case of cerebral vascular accident and a wake-up stroke: a case report.Journal of medical case reports · 2025Article
- APIS: a paired CT-MRI dataset for ischemic stroke segmentation - methods and challenges.Scientific reports · 2024Article
- Machine learning based outcome prediction of large vessel occlusion of the anterior circulation prior to thrombectomy in patients with wake-up stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- An Unexpected Outcome of an Ischemic Stroke on the Reward Pathways in the Human Brain.HCA healthcare journal of medicine · 2024Article
- Outcomes and Complications Associated with Mechanical Thrombectomy in the Treatment of Acute Ischemic Stroke.Cardiology and cardiovascular medicine · 2024Article
- Nanotechnology in Stroke: New Trails with Smaller Scales.Biomedicines · 2023Review
- Advances in mechanical thrombectomy for acute ischaemic stroke.BMJ medicine · 2023Review
- Ischemic stroke with unknown onset of symptoms: current scenario and perspectives for the future.Arquivos de neuro-psiquiatria · 2022Article
- Multicentre registration of wake-up stroke in China (MCRWUSC): a protocol for a prospective, multicentre, registry-based cohort study.BMJ open · 2022Article
- Rapid Thrombolysis Protocol: Results from a Before-and-after Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Temporal trends in reperfusion therapy for patients with acute ischemic stroke.Journal of the American College of Emergency Physicians open · 2022Article
- Article
- Acute ischemic stroke care in Germany - further progress from 2016 to 2019.Neurological research and practice · 2021Article
- A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and barbiturate infusion during emergency carotid endarterectomy for acute stroke after failed tPA or beyond 24-hour window of opportunity.Annals of translational medicine · 2020Review
- Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit.Journal of neurology · 2020Article
- A New Era of Extended Time Window Acute Stroke Interventions Guided by Imaging.The Neurohospitalist · 2020Review
- Poster Viewing Sessions PB01-B01 to PB03-V09.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- CT-guided thrombolytic treatment of patients with wake-up strokes.eNeurologicalSci · 2019Article
- Endovascular Thrombectomy in Wake-Up Stroke and Stroke with Unknown Symptom Onset.AJNR. American journal of neuroradiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wake-up stroke, defined as the situation where a patient awakens with stroke symptoms that were not present prior to falling asleep, represents roughly 1 in 5 acute ischemic strokes and remains a therapeutic dilemma. Patients with wake-up stroke were excluded from most ischemic stroke treatment trials and are often not eligible for acute reperfusion therapy in clinical practice, leading to poor outcomes. Studies of neuroimaging with standard noncontrast computed tomography (CT), magnetic resonance imaging (MRI), and multimodal perfusion-based CT and MRI suggest wake-up stroke may occur shortly before awakening and may assist in selecting patients for acute reperfusion therapies. Pilot studies of wake-up stroke treatment based on these neuroimaging features are promising but have limited generalizability. Ongoing randomized treatment trials using neuroimaging-based patient selection may identify a subset of patients with wake-up stroke that can safely benefit from acute reperfusion therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.