ArticleCytoJournal2015
Amyloidoma secondary to insulin injection: Cytologic diagnosis and pitfalls.
Article in CytoJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Gangliosides GM3 And GD3 Modulate Insulin Aggregation Pathways and Reduce Cytotoxicity Through Structural Remodeling.bioRxiv : the preprint server for biology · 2026Article
- Differences in clinicopathological characteristics between lipohypertrophy and localized insulin-derived amyloidosis: A scoping review.Chronic diseases and translational medicine · 2024Article
- Quantitative evaluation of insulin-induced abdominal subcutaneous dystrophic tissue using shear wave elastography.Journal of diabetes investigation · 2022Article
- Insulin-derived amyloidosis: The insulin ball, amyloidoma.JAAD case reports · 2020Article
- A Small Molecule Impedes Insulin Fibrillation: Another New Role of Phenothiazine Derivatives.ChemistryOpen · 2018Article
- Progressive insulin-derived amyloidosis in a patient with type 2 diabetes.Case reports in plastic surgery & hand surgery · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloidomas are rare tumors composed of deposits of amyloid protein not associated with systemic amyloidosis. They can present as an initial manifestation of a systemic disease process or can be a completely localized phenomenon. We present a case of amyloidoma associated with insulin injection site found incidentally in an 80-year-old male with multiple co-morbidities who presented with diverticulitis associated bleeding. A subcutaneous abdominal mass was found on physical examination. Imaging revealed a 5 cm × 1.6 cm homogenous subcutaneous lesion. A fine-needle aspiration (FNA) and core biopsy were performed under ultrasound guidance to reveal amorphous material proven to be amyloidosis at insulin injection sites (AIns) type amyloid. The patient had no treatment for this lesion and has had his care triaged to his more serious health problems. This is the first case of AIns type amyloidoma associated with insulin injection site reported in cytology literature. We highlight the cytologic findings and diagnostic pitfalls. As the incidence of diabetes is increasing, cytopathologists may encounter this lesion more often on FNA.
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