Evidence map›Paper›PMID 26288391›Full record

Trial reportAnnals of the American Thoracic Society2015

Executive Function, Survival, and Hospitalization in Chronic Obstructive Pulmonary Disease. A Longitudinal Analysis of the National Emphysema Treatment Trial (NETT).

James W Dodd, Paul Novotny, Frank C Sciurba, Roberto P Benzo, NETT Research Group

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Moderate-to-Severe Obstructive Sleep Apnea and Cognitive Function Impairment in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2020
    Article
  6. Reduced Attention in Former Smokers with and without COPD.International journal of behavioral medicine · 2019
    Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

James W Dodd1 Academic Respiratory Unit, University of Bristol, Bristol, United Kingdom.
Paul Novotny2 Mindful Breathing Laboratory, Mayo Clinic, Rochester, Minnesota; and.
Frank C Sciurba3 COPD Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Roberto P Benzo2 Mindful Breathing Laboratory, Mayo Clinic, Rochester, Minnesota; and.
NETT Research Group
Mayo Clinic · USUniversity of Bristol · GBUniversity of Pittsburgh · US

Funding

Impact of CPAP on Functional Outcomes in Milder OSAR01HL076101 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEAVER, TERRI ELIZABETH · 2003 to 2006
$2.6M
Multicomponent Intervention to Decrease COPD-Related HospitalizationsR01HL094680 · NHLBI · MAYO CLINIC ROCHESTER · PI BENZO, ROBERTO PABLO · 2010 to 2014
$2.1M
Modeling of Lung HIV Cytokine/Chemokine NetworksR01HL076114 · NHLBI · BOSTON MEDICAL CENTER · PI SKOLNIK, PAUL R · 2003 to 2006
$1.8M
Training Program in Academic Pulmonary MedicineT32HL076118 · NHLBI · EMORY UNIVERSITY · PI HART, C MICHAEL · 2004 to 2013
$1.7M
Neurotrophins and Development of Baroreceptor Pathways.R01HL076113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI BALKOWIEC, AGNIESZKA Z · 2005 to 2009
$1.5M
CLINICAL COORDINATING CENTER FOR LVRS-N01HR76119-268076119-268076119N01HR076119 · HR · JOHNS HOPKINS UNIVERSITY · PI PIANTADOSI, STEVEN · 1997 to 2006
$871k
Cardiovascular Development and Disease in the YoungT32HL076116 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROSEN, MICHAEL R. · 2004 to 2008
$577k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076118 · HR · UNIVERSITY OF WASHINGTON · PI ALBERT, RICHARD K · 1997 to 2000
$225k
LUNG VOLUME REDUCTION SURGERY--CLINICAL CENTERN01HR076113 · HR · UNIVERSITY OF PENNSYLVANIA · PI KAISER, LARRY · 1997 to 2000
$208k
CLNICAL CENTER FOR LVRSN01HR076104 · HR · CEDARS-SINAI MEDICAL CENTER · PI MCKENNA, RICHARD · 1997 to 2000
$153k
CLNICAL CENTER FOR THE LVRSN01HR076102 · HR · BRIGHAM AND WOMEN'S HOSPITAL · PI REILLY, JOHN J · 1997 to 2000
$150k
CLINICAL CENTER FOR LVRSN01HR076114 · HR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KEENAN, ROBERT J · 1997 to 2000
$147k
NHLBI NIH HHS 5R01HL094680-05NHLBI NIH HHS N01 HR076101NHLBI NIH HHS N01 HR076102NHLBI NIH HHS N01 HR076103NHLBI NIH HHS N01 HR076104NHLBI NIH HHS N01 HR076105NHLBI NIH HHS N01 HR076106NHLBI NIH HHS N01 HR076107NHLBI NIH HHS N01 HR076108NHLBI NIH HHS N01 HR076109NHLBI NIH HHS N01 HR076110NHLBI NIH HHS N01 HR076111NHLBI NIH HHS N01 HR076112NHLBI NIH HHS N01 HR076113NHLBI NIH HHS N01 HR076114NHLBI NIH HHS N01 HR076115NHLBI NIH HHS N01 HR076116NHLBI NIH HHS N01 HR076118NHLBI NIH HHS N01 HR076119NHLBI NIH HHS R01 HL094680
6 · The paper itself

Abstract

rationaleCognitive dysfunction has been demonstrated in chronic obstructive pulmonary disease (COPD), but studies are limited to cross-sectional analyses or incompletely characterized populations.

objectivesWe examined longitudinal changes in sensitive measures of executive function in a well-characterized population of patients with severe COPD.

methodsThis study was performed on patients enrolled in the National Emphysema Treatment Trial. To assess executive function, we analyzed trail making (TM) A and B times at enrollment in the trial (2,128 patients), and at 12 (731 patients) and 24 months (593 patients) after enrollment, adjusted for surgery, marriage status, age, education, income, depression, PaO2, PaCO2, and smoking. Associations with survival and hospitalizations were examined using Cox regression and linear regression models. MEASUREMENTS AND MAIN

resultsThe average age of the patients was 66.4 years, and the average FEV1 was 23.9% predicted. At the time of enrolment, 38% had executive dysfunction. Compared with those who did not, these patients were older, less educated, had higher oxygen use, higher PaCO2, worse quality of life as measured by the St. George's Respiratory Quotient, reduced well-being, and lower social function. There was no significant change over 2 years in TM A or B times after adjustment for covariables. Changes in TM B times were modestly associated with survival, but changes in TM B-A times were not. Changes in TM scores were not associated with frequency of hospitalization. Lung function, PaO2, smoking, survival, and hospitalizations were not significantly different in those with executive dysfunction.

conclusionsIn this large population of patients with severe emphysema and heavy cigarette smoking exposure, there was no significant decline over 2 years in cognitive executive function as measured by TM tests. There was no association between executive function impairment and frequency of hospitalization, and there was a possible modest association with survival. It is plausible that cerebrovascular comorbidities explain previously described cognitive pathology in COPD.

Indexed as

Executive FunctionHospitalizationAgedCognitive DysfunctionComorbidityFemaleHumansLinear ModelsLongitudinal StudiesMaleMiddle AgedPulmonary Disease, Chronic ObstructivePulmonary EmphysemaQuality of LifeSeverity of Illness IndexSmokingchronic obstructive pulmonary diseasecognitionexecutive functionhospitalizationsurvival

Identifiers

PMID26288391
PMCPMC4627422
OpenAlexW1909461176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.