ArticleThe Journal of investigative dermatology2015
Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Fibroblast Heterogeneity in Healthy and Wounded Skin.Cold Spring Harbor perspectives in biology · 2022Article
- Article
- Article
- Review
- Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds.eLife · 2020Article
- Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease.Current rheumatology reports · 2020Review
- Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding.Seminars in cell & developmental biology · 2020Review
- Review
- Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds.Nature communications · 2019Article
- Skin Cell Heterogeneity in Development, Wound Healing, and Cancer.Trends in cell biology · 2018Review
- Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth.The Journal of investigative dermatology · 2017Article
- Reply to Chi et al.The Journal of investigative dermatology · 2017Article
- Stabilization of β-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle.The Journal of investigative dermatology · 2017Article
- CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth.The Biochemical journal · 2016Article
- Activating β-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity.The FEBS journal · 2016Article
- Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing.Development (Cambridge, England) · 2016Article
- β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.The Journal of investigative dermatology · 2016Article
- Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.Nature communications · 2016Article
- Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth.PloS one · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Prominin-1/CD133 (Prom1) is expressed by fibroblasts in the dermal papilla (DP) of the hair follicle (HF). By examining endogenous Prom1 expression and expression of LacZ in the skin of Prom1CreERLacZ (Prom1C-L) mice, in which a CreERT2-IRES-nuclear LacZ cassette is knocked into the first ATG codon of Prom1, we confirmed that Prom1 is expressed in the DP of all developing HFs and also by postnatal anagen follicles. To analyze the fate of Prom1+ DP cells, we crossed Prom1C-L mice with Rosa26-CAG flox/stop/flox tdTomato reporter mice and applied 4-hydroxytamoxifen (4OHT) to back skin at postnatal day (P) 1 and P2. We detected tdTomato+ cells in ~50% of DPs. The proportion of labeled cells per DP increased between P5 and P63, while the total number of cells per DP declined. Following full thickness wounding, there was no migration of tdTomato-labeled cells out of the DP. When β-catenin was activated in Prom1+ DP cells there was an increase in the size of anagen and telogen DP, but the proportion of tdTomato-labeled cells did not increase. We conclude that Prom1+ DP cells do not contribute to dermal repair but are nevertheless capable of regulating DP size via β-catenin-mediated intercellular communication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.