ArticlePrenatal diagnosis2015
Trophoblast retrieval and isolation from the cervix (TRIC) is unaffected by early gestational age or maternal obesity.
Article in Prenatal diagnosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is cervical swab an efficient method for developing a new noninvasive prenatal diagnostic test for numerical and structural chromosome anomalies?Turkish journal of medical sciences · 2021Pooled it
- Trophoblast Retrieval from the Cervix (TRIC) Across Early Gestation: A Multi-Method Assessment of Extravillous Trophoblast Recovery.International journal of molecular sciences · 2026Article
- Common chromosomal aneuploidy testing using non-invasive trophoblast retrieval and isolation from the cervix (TRIC) in pregnant women.Archives of gynecology and obstetrics · 2025Article
- Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison.Frontiers in immunology · 2025Article
- A Novel Paradigm for Non-Invasive Prenatal Genetic Screening: Trophoblast Retrieval and Isolation from the Cervix (TRIC).Diagnostics (Basel, Switzerland) · 2023Review
- Trophoblast retrieval from the cervical canal to predict abnormal pregnancy early in gestation: a pilot study.BMC pregnancy and childbirth · 2023Article
- Advanced Strategy of Trophoblasts Retrieval and Isolation from the Cervix (TRIC): Comparison of Two HLA-G Antibodies for Immunomagnetic Isolation of Trophoblasts.Journal of personalized medicine · 2022Article
- Tricky TRIC: A replication study using trophoblast retrieval and isolation from the cervix to study genetic birth defects.Prenatal diagnosis · 2022Article
- Nanotechnologies in Obstetrics and Cancer during Pregnancy: A Narrative Review.Journal of personalized medicine · 2022Review
- Isolation and Enrichment of Circulating Fetal Cells for NIPD: An Overview.Diagnostics (Basel, Switzerland) · 2021Review
- Overview and recent developments in cell-based noninvasive prenatal testing.Prenatal diagnosis · 2021Review
- The effect of maternal body mass index and gestational age on circulating trophoblast yield in cell-based noninvasive prenatal testing.Prenatal diagnosis · 2020Article
- Considerations for whole exome sequencing unique to prenatal care.Human genetics · 2020Review
- Optimization Protocol of Fixation Method for Trophoblast Retrieval from the Cervix (TRIC): A Preliminary Study.Diagnostics (Basel, Switzerland) · 2020Article
- A Rapid Method for Label-Free Enrichment of Rare Trophoblast Cells from Cervical Samples.Scientific reports · 2019Article
- Endocervical trophoblast for interrogating the fetal genome and assessing pregnancy health at five weeks.European journal of medical genetics · 2019Article
- Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.Human reproduction update · 2018Review
- Article
- Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal.Science translational medicine · 2016Article
- Trophoblast Retrieval and Isolation From the Cervix for Noninvasive, First Trimester, Fetal Gender Determination in a Carrier of Congenital Adrenal Hyperplasia.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveThe objective of this study is to evaluate whether trophoblast yield obtained by trophoblast retrieval and isolation from the cervix (TRIC) is affected by pregnancy outcome, gestational age (GA) at retrieval, maternal body mass index (BMI), parity, or maternal age.
methodsTRIC was performed on 224 ongoing pregnancies between 5 and 20 weeks of GA. Trophoblast cells were isolated from cervical cells using anti-human leukocyte antigen-G antibody coupled to magnetic nanoparticles. Purity was assessed by the percentage of isolated cells that express β-hCG. Patient records were monitored until delivery, and pregnancy outcomes were determined. Trophoblast yield was compared with GA at time of collection, maternal BMI, parity, maternal age, and outcome of pregnancy, using linear regression.
resultsThere was no effect of GA, maternal BMI, parity, and maternal age on trophoblast yield. Trophoblast yield decreased significantly with early pregnancy loss compared with uncomplicated pregnancies that delivered at term. Trophoblast yield with preeclampsia or intrauterine growth restriction was decreased compared with healthy term outcomes; however, they did not reach statistical significance.
conclusionsIf TRIC becomes available as a method for non-invasive prenatal testing, our data demonstrate that it is unaffected by BMI and is useful as early as 5 weeks of GA.
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