ArticleScientific reports2015
Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Employment of Two-Acid Promoter System in Pictet-Spengler Reaction: A Robust Two-Step Synthesis of Aza-Heterocycles.ACS omega · 2026Article
- A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential.Molecular diversity · 2025Review
- Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts.RSC advances · 2023Article
- Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles.Frontiers in chemistry · 2023Article
- Structural diversity-guided optimization of carbazole derivatives as potential cytotoxic agents.Frontiers in chemistry · 2023Article
- Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts.International journal of molecular sciences · 2022Article
- Insights into the Formations of Host-Guest Complexes Based on the Benzimidazolium Based Ionic Liquids-β-Cyclodextrin Systems.ACS physical chemistry Au · 2022Article
- β-Carboline-based molecular hybrids as anticancer agents: a brief sketch.RSC medicinal chemistry · 2021Review
- Hypochlorite-Activated Fluorescence Emission and Antibacterial Activities of Imidazole Derivatives for Biological Applications.Frontiers in chemistry · 2021Article
- Origin identification of Chinese Maca using electronic nose coupled with GC-MS.Scientific reports · 2019Article
- Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores.MedChemComm · 2019Article
- Synthesis and biological study of acridine-based imidazolium salts.RSC advances · 2018Article
- Synthesis, characterization, and in vitro SAR evaluation of N,N'-bis(arylmethyl)-CBioorganic & medicinal chemistry letters · 2017Article
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7 authors.
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Abstract
A series of novel N-substituted carbazole imidazolium salt derivatives has been prepared and investigated for their cytotoxic activity against five human tumor cell lines by MTS assay. The results indicated that the existence of 5,6-dimethyl-benzimidazole ring, substitution of the imidazolyl-3-position with a 2-bromobenzyl or naphthylacyl group, as well as alkyl chain length between carbazole and imidazole ring were important for the antitumor activity. Compound 61, bearing a 2-bromobenzyl substituent at position-3 of the 5,6-dimethyl-benzimidazole, showed powerful inhibitory activities and was more selective to HL-60, SMMC-7721, MCF-7 and SW480 cell lines with IC50 values 0.51-2.48 μM. Mechanism of action studies revealed that this new compound could remarkably induce cell cycle arrest and apoptosis in SMMC-7721 cells. This work provides alternative novel way for future drug development based on carbazole and imidazolium salt scaffolds.
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