ArticleJAMA dermatology2015
Growth-Curve Modeling of Nevi With a Peripheral Globular Pattern.
Article in JAMA dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 45 citations in OpenAlex.
- Anamnestic, clinical, and dermoscopic predictors of malignancy in melanocytic lesions with peripheral globules: a retrospective study.Dermatology reports · 2026Article
- Predictors of malignancy in melanocytic lesions presenting as new lesions compared to baseline total body photography: A case-control study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- AI-assisted Total Body Dermoscopic Evaluation of Changes in Melanocytic Nevi during Pregnancy: A Prospective, Comparative Study of 2,799 Nevi.Acta dermato-venereologica · 2025Article
- Melanocytic Lesions with Peripheral Globules: Proposal of an Integrated Management Algorithm.Dermatology practical & conceptual · 2023Review
- The long-term evolution of melanocytic nevi among high-risk adults.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi.The Journal of investigative dermatology · 2022Article
- Association between the dermoscopic morphology of peripheral globules and melanocytic lesion diagnosis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Temporal Changes in Size and Dermoscopic Patterns of New and Existing Nevi in Adolescents.The Journal of investigative dermatology · 2019Observational
- Sequential digital dermatoscopic imaging of patients with multiple atypical nevi.Dermatology practical & conceptual · 2018Article
- The study of nevi in children: Principles learned and implications for melanoma diagnosis.Journal of the American Academy of Dermatology · 2016Review
- Biologically distinct subsets of nevi.Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
importanceAlthough nevi with a peripheral rim of globules (peripheral globular nevi [PGN]) observed with dermoscopy are associated with enlarging melanocytic nevi, their actual growth dynamics remain unknown. Because change is a sensitive but nonspecific marker for melanoma, beginning to understand the growth patterns of nevi may improve the ability of physicians to differentiate normal from abnormal growth and reduce unnecessary biopsies.
objectiveTo study the growth dynamics and morphologic evolution of PGN on dermoscopy. DESIGN, SETTING, AND
participantsA total of 84 participants with 121 PGN from September 1, 1999, through May 1, 2013, were identified retrospectively. Cohorts were recruited from the Memorial Sloan Kettering Cancer Center; Melanoma Unit of the Hospital Clinic, University of Barcelona; and Study of Nevi in Children. All 3 cohorts underwent longitudinal monitoring with serial dermoscopic imaging of their PGN. Data analysis was performed from May 1, 2014, through April 1, 2015. MAIN OUTCOMES AND MEASURES: Establishment of the natural growth curve of PGN. The secondary aim was to establish the median time to growth cessation in those PGN for which the size eventually stabilized and/or had begun to decrease during the study period.
resultsThe median duration of follow-up was 25.1 (range, 2.0-114.4) months. Most of the nevi (116 [95.9%]) enlarged at some point during sequential monitoring. The rate of increase in the surface area of PGN varied among cohorts and ranged from -0.47 to 2.26 mm2/mo (mean rate, 0.25 [95% CI, 0.14-0.36] mm2/mo). The median time to growth cessation in the 26 PGN that stabilized or decreased in size (21.5%) was 58.6 months. All lesions changed in a symmetric manner and 91 (75.2%) displayed a decrease in the density of peripheral globules over time. CONCLUSIONS AND RELEVANCE: Nevi displaying a peripheral globular pattern enlarged symmetrically with apparent growth cessation occurring during a span of 4 to 5 years. Our results reiterate the important concept that not all growth is associated with malignancy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.