ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2016
Factors that influence the suitability of human organ-cultured corneas.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Clinical and epidemiological factors affecting donor corneal endothelial cell density.BMJ open ophthalmology · 2025Article
- Comparison of the structural integrity and quality of corneal endothelium stored in organ culture storage medium versus Eusol-C.Cell and tissue banking · 2024Article
- Gram stain and addition of amphotericin B to improve the microbial safety of human donor corneas.Cell and tissue banking · 2022Article
- Induction of Corneal Epithelial Differentiation of Induced Pluripotent and Orbital Fat-Derived Stem Cells Seeded on Decellularized Human Corneas.Stem cell reviews and reports · 2022Article
- Approval rates for corneal donation and the origin of donor tissue for transplantation at a university-based tertiary referral center with corneal subspecialization hosting a LIONS Eye Bank.BMC ophthalmology · 2022Article
- Cornea Procurement and Processing up to 72 Hours: No Risk for Cornea Transplant Quality.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Intensive care unit time and prolonged enucleation to processing interval are associated with donor cornea contamination.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Donor-Dependent Factors Influencing Contamination Rates of Conjunctival Swabs of Human Donor Eyes.Annals of transplantation · 2019Article
- Factors influencing the contamination rates of the conjunctival swabs and organ culture media of human donor eyes.Medicine · 2018Observational
- Amniotic Membrane Transplantation in Reconstructive and Regenerative Ophthalmology.Annals of transplantation · 2018Article
- Trends in corneal transplantation at the University Eye Hospital in Tübingen, Germany over the last 12 years: 2004 - 2015.PloS one · 2018Article
- The Evolution of Corneal Transplantation.Annals of transplantation · 2017Article
- Review
- Article
- Effect of Organ Scandal on Corneal Donation Rate and Organ Donors at a German University Hospital.Annals of transplantation · 2017Article
- Organ transplantation scandal influencing corneal donation rate.International journal of ophthalmology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose was to assess the influence of donor and storage factors on the suitability of organ-cultured corneas for transplantation.
methodsData from 1340 donor corneas stored between 2009 and 2015 were analyzed retrospectively. Logistic regression analysis was used to assess the influence of different factors on the suitability of grafts for transplantation.
resultsForty-one percent (553/1340) of corneas were discarded. The leading causes were medical contraindication (20.2 %) and poor endothelial quality (19.3 %). Donor age influenced suitability for transplantation significantly. Corneas from donors aged 80 years and older were more likely to be discarded because of endothelial insufficiency (P < 0.0001). The cause of donor death including infection and multiple organ dsyfunction syndrom (MODS) increased the risk of bacterial or fungal contamination during organ culture (P = 0.007 and P = 0.014, respectively). Prolonged time between death and enucleation was associated with an increased risk of unsuitability for transplantation (P < 0.0001). The amount of time between death and corneoscleral disc excision and duration of storage influenced the suitability for transplantation (P = 0.0007 and P < 0.0001, respectively).
conclusionDonor age, cause of death, storage time, death to enucleation and death to disc excision times influenced transplantation suitability. The percentage of discarded corneas may be reduced by shortening storage time, death to enucleation, and death to corneoscleral disc excision times. Setting a maximum donor age could reduce the percentage of discarded corneas. However, as long as there is a lack of donor corneas, we do not recommend any donor age limit.
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