ReviewJournal of clinical medicine2015
Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury.
Review in Journal of clinical medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- CaNeurochemical research · 2026Article
- The roles of pleiotrophin in brain injuries: a narrative review of the literature.Annals of medicine · 2025Review
- Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions.Children (Basel, Switzerland) · 2025Review
- Endocrine dysfunction post-traumatic brain injury: challenges and therapeutic approaches.Acta neurologica Belgica · 2025Review
- Extracranial Effects of Traumatic Brain Injury: A Narrative Review.Clinics and practice · 2025Review
- New diagnostic approach to central hypothyroidism after traumatic brain injury in children and adolescents.European thyroid journal · 2025Article
- Longitudinal healthcare use after pediatric brain injury: A population-based birth cohort study.PloS one · 2025Article
- Article
- Cohort profile: a population-based birth cohort of traumatic brain injury in Ontario, Canada.European journal of epidemiology · 2024Article
- Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat.The Journal of endocrinology · 2024Article
- Neuroendocrine Disruptions Following Head Injury.Current neurology and neuroscience reports · 2023Review
- An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges.Diagnostics (Basel, Switzerland) · 2023Article
- Endocrine Abnormalities in Children With Traumatic Brain Injury at a Tertiary Care Center.Cureus · 2023Article
- Article
- Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury.Brain, behavior, & immunity - health · 2022Article
- Evidence Limitations in Determining Sexually Dimorphic Outcomes in Pediatric Post-Traumatic Hypopituitarism and the Path Forward.Frontiers in neurology · 2020Review
- Lifelong consequences of brain injuries during development: From risk to resilience.Frontiers in neuroendocrinology · 2019Review
- Review
- Hypopituitarism After Traumatic Brain Injury.Cureus · 2019Review
- Should We Assess Pituitary Function in Children After a Mild Traumatic Brain Injury? A Prospective Study.Frontiers in endocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injuries (TBI) are common occurrences in childhood, often resulting in long term, life altering consequences. Research into endocrine sequelae following injury has gained attention; however, there are few studies in children. This paper reviews the pathophysiology and current literature documenting risk for endocrine dysfunction in children suffering from TBI. Primary injury following TBI often results in disruption of the hypothalamic-pituitary-adrenal axis and antidiuretic hormone production and release, with implications for both acute management and survival. Secondary injuries, occurring hours to weeks after TBI, result in both temporary and permanent alterations in pituitary function. At five years after moderate to severe TBI, nearly 30% of children suffer from hypopituitarism. Growth hormone deficiency and disturbances in puberty are the most common; however, any part of the hypothalamic-pituitary axis can be affected. In addition, endocrine abnormalities can improve or worsen with time, having a significant impact on children's quality of life both acutely and chronically. Since primary and secondary injuries from TBI commonly result in transient or permanent hypopituitarism, we conclude that survivors should undergo serial screening for possible endocrine disturbances. High indices of suspicion for life threatening endocrine deficiencies should be maintained during acute care. Additionally, survivors of TBI should undergo endocrine surveillance by 6-12 months after injury, and then yearly, to ensure early detection of deficiencies in hormonal production that can substantially influence growth, puberty and quality of life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.