ArticleMolecules (Basel, Switzerland)2015
Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cobalt catalysis in organic synthesis: a powerful tool in the synthesis of natural products and pharmaceutically active compounds.RSC advances · 2026Review
- Organelle genome architecture ofFrontiers in plant science · 2026Article
- Diterpenes: Nature's Hidden Gems of Immunomodulation.International journal of molecular sciences · 2025Review
- An Ethnopharmacological Survey on Medicinally Important Plants of Genus Salvia.Combinatorial chemistry & high throughput screening · 2025Review
- Stereocontrolled Synthesis and Structural Revision of Plebeianiol A.Organic letters · 2021Article
- Effect of Sunlight Radiation on the Growth and Chemical Constituents of Salvia plebeia R.Br.Molecules (Basel, Switzerland) · 2017Article
- Evaluation of the Nano-TiO2 as a Novel Deswelling Material.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
11 authors.
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Abstract
A new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2-5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0-29.6 µM. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1-3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0-23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation.
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Registered trials
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