ArticleHippocampus2016
Age differences in hippocampal subfield volumes from childhood to late adulthood.
Article in Hippocampus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- Magnetic resonance elastography of the ageing brain in normal and demented populations: A systematic review.Human brain mapping · 2022Pooled it
- Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults.Hippocampus · 2026Article
- Distinct spatial associations of adversity with hippocampal macro- and microstructure in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- High-resolution MRI evidence for age- and sex-related changes in hippocampal subfield volume during healthy aging.GeroScience · 2026Article
- Hippocampal Development and Epilepsy: Insights from Organoid Models.Brain sciences · 2025Review
- Hippocampal subfield activity in schizophrenia: Effects of the disease course.Schizophrenia research · 2025Article
- Sex-specific trajectories of hippocampal aging: structural changes and asymmetry across the lifespan.Neuroradiology · 2025Article
- Maturation of Hippocampal Subfields in Young Adulthood and Its Relationship With Cognition.Human brain mapping · 2025Article
- Age-related differences in the relationship between sustained attention and associative memory and Memory-Guided inference.Cognitive, affective & behavioral neuroscience · 2025Article
- Article
- A data integration method for new advances in development cognitive neuroscience.Developmental cognitive neuroscience · 2024Article
- Inter-Software Consistency on the Estimation of Subcortical Structure Volume in Different Age Groups.Human brain mapping · 2024Article
- A (sub)field guide to quality control in hippocampal subfield segmentation on high-resolution THuman brain mapping · 2024Review
- Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke.Brain and behavior · 2024Article
- Age-specific prevalence of the different clinical presentations of AD and FTD in young-onset dementia.Journal of neurology · 2024Article
- Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.Pain reports · 2024Article
- Goal-directed learning in adolescence: neurocognitive development and contextual influences.Nature reviews. Neuroscience · 2024Review
- Smaller anterior hippocampal subfields in the early stage of psychosis.Translational psychiatry · 2024Article
- Altered Sex Differences in Hippocampal Subfield Volumes in Schizophrenia.Schizophrenia bulletin · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The hippocampus is composed of distinct subfields: the four cornu ammonis areas (CA1-CA4), dentate gyrus (DG), and subiculum. The few in vivo studies of human hippocampal subfields suggest that the extent of age differences in volume varies across subfields during healthy childhood development and aging. However, the associations between age and subfield volumes across the entire lifespan are unknown. Here, we used a high-resolution imaging technique and manually measured hippocampal subfield and entorhinal cortex volumes in a healthy lifespan sample (N = 202), ages 8-82 yrs. The magnitude of age differences in volume varied among the regions. Combined CA1-2 volume evidenced a negative linear association with age. In contrast, the associations between age and volumes of CA3-DG and the entorhinal cortex were negative in mid-childhood and attenuated in later adulthood. Volume of the subiculum was unrelated to age. The different magnitudes and patterns of age differences in subfield volumes may reflect dynamic microstructural factors and have implications for cognitive functions across the lifespan. © 2015 Wiley Periodicals, Inc.
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