Evidence map›Paper›PMID 26286813›Full record

ArticleVirchows Archiv : an international journal of pathology2015

Langerhans cell sarcoma following marginal zone lymphoma: expanding the knowledge on mature B cell plasticity.

Maria Raffaella Ambrosio, Giulia De Falco, Bruno Jim Rocca, Aurora Barone, Teresa Amato, Cristiana Bellan, Stefano Lazzi, Lorenzo Leoncini

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  14. Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.Virchows Archiv : an international journal of pathology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Maria Raffaella AmbrosioDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy. maradot@libero.it.
Giulia De FalcoDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
Bruno Jim RoccaDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
Aurora BaroneDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
Teresa AmatoDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
Cristiana BellanDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
Stefano LazziSection of Pathology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Lorenzo LeonciniDepartment of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy.
University of Siena · ITAzienda Ospedaliera Universitaria Senese · ITOspedale di Circolo di Busto Arsizio · ITQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of unidirectional differentiation of the haematopoietic stem cell has been challenged after recent findings that human B cell progenitors and even mature B cells can be reprogrammed into histiocytic/dendritic cells by altering expression of lineage-associated transcription factors. The conversion of mature B cell lymphomas to Langerhans cell neoplasms is not well documented. Three previous reports have described clonally related follicular lymphoma and Langerhans cell tumours, whereas no case has been published of clonally related marginal zone lymphoma and Langerhans cell sarcoma. We describe the case of a 77-year-old patient who developed a Langerhans cell sarcoma and 6 years later a nodal marginal zone lymphoma. Mutation status examination showed 100 % gene identity to the germline sequence, suggesting direct trans-differentiation or dedifferentiation of the nodal marginal zone lymphoma to the Langerhans cell sarcoma rather than a common progenitor. We found inactivation of paired box 5 (PAX-5) in the lymphoma cells by methylation, along with duplication of part of the long arm of chromosomes 16 and 17 in the sarcoma cells. The absence of PAX-5 could have triggered B cells to differentiate into macrophages and dendritic cells. On the other hand, chromosomal imbalances might have activated genes involved in myeloid lineage maturation, transcription activation and oncogenesis. We hypothesize that this occurred because of previous therapies for nodal marginal zone lymphoma. Better understanding of this phenomenon may help in unravelling the molecular interplay between transcription factors during haematopoietic lineage commitment and may expand the spectrum of clonally related mature B cell neoplasms and Langerhans cell tumours.

Indexed as

Cell PlasticityAgedB-LymphocytesDNA MethylationHumansImmunophenotypingLangerhans Cell SarcomaLymphoma, B-Cell, Marginal ZoneMalePAX5 Transcription FactorPAX5 protein, humanPAX5 Transcription FactorArray comparative genomic hybridizationGeneScanLangerhans cell sarcomaMarginal zone lymphomaTrans-differentiation

Identifiers

PMID26286813
OpenAlexW1657571909

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.